Abstract | BACKGROUND: METHODS:
Cerebral ischemia was modeled in male Sprague-Dawley rats (n = 32) by occluding the right middle cerebral artery for 1 h, followed by intravenous tPA administration. Rats were randomly divided into control and isoflurane post-treatment group, and isoflurane post-treatment group was post-treated by administering 1.5% isoflurane for 1 h from the start of reperfusion. Twenty-four h after reperfusion, neurobehavioral changes were assessed. The extent of cerebral infarction and intracranial hemorrhage were also assessed by quantification of infarction volume and cerebral hemoglobin concentration from brain tissue, respectively. RESULTS: CONCLUSIONS:
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Authors | Eun Jung Kim, So Yeon Kim, Jae Hoon Lee, Jeong Min Kim, Jin-Soo Kim, Jung Ik Byun, Bon-Nyeo Koo |
Journal | Korean journal of anesthesiology
(Korean J Anesthesiol)
Vol. 68
Issue 3
Pg. 281-6
(Jun 2015)
ISSN: 2005-6419 [Print] Korea (South) |
PMID | 26045932
(Publication Type: Journal Article)
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