HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Epigenetic dynamics in immunity and autoimmunity.

Abstract
A tightly synchronized and spatial-temporal interaction among regulatory proteins within genomic DNA and chromatin is essential for cellular commitment and differentiation. During development and activation of the immune system, a complex regulatory network that involves induction of lineage instructive transcription factors, installation or removal of histone modifications and changes in DNA methylation patterns locally orchestrate the three-dimensional chromatin structure and determine immune cell fate and immune responses. In autoimmune diseases, disease associated epigenetic marks and dynamic changes control the dysregulated immune system, thus determining the disease development and clinical phenotype. In this review, we introduce the dynamic epigenetic regulation of DNA and histones, summarize the epigenetic regulatory mechanisms in the development and differentiation of some important immune cell subsets and provide new insights for the pathogenesis of autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis and Type 1 diabetes. This article is part of a Directed Issue entitled: Epigenetics dynamics in development and disease.
AuthorsMing Zhao, Zijun Wang, Susan Yung, Qianjin Lu
JournalThe international journal of biochemistry & cell biology (Int J Biochem Cell Biol) Vol. 67 Pg. 65-74 (Oct 2015) ISSN: 1878-5875 [Electronic] Netherlands
PMID26026281 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
CopyrightCopyright © 2015 Elsevier Ltd. All rights reserved.
Chemical References
  • Chromatin
  • Histones
Topics
  • Acetylation
  • Arthritis, Rheumatoid (genetics, immunology, pathology)
  • Autoimmunity
  • Chromatin (chemistry, immunology)
  • DNA Methylation
  • Diabetes Mellitus, Type 1 (genetics, immunology, pathology)
  • Epigenesis, Genetic
  • Genetic Predisposition to Disease
  • Histones (immunology, metabolism)
  • Humans
  • Immunity, Innate
  • Lupus Erythematosus, Systemic (genetics, immunology, pathology)
  • Lymphocyte Subsets (immunology, pathology)
  • Multiple Sclerosis (genetics, immunology, pathology)
  • Phenotype

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: