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Low Frequency Electromagnetic Field Conditioning Protects against I/R Injury and Contractile Dysfunction in the Isolated Rat Heart.

Abstract
Low frequency electromagnetic field (LF-EMF) decreases the formation of reactive oxygen species, which are key mediators of ischemia/reperfusion (I/R) injury. Therefore, we hypothesized that the LF-EMF protects contractility of hearts subjected to I/R injury. Isolated rat hearts were subjected to 20 min of global no-flow ischemia, followed by 30 min reperfusion, in the presence or absence of LF-EMF. Coronary flow, heart rate, left ventricular developed pressure (LVDP), and rate pressure product (RPP) were determined for evaluation of heart mechanical function. The activity of cardiac matrix metalloproteinase-2 (MMP-2) and the contents of coronary effluent troponin I (TnI) and interleukin-6 (IL-6) were measured as markers of heart injury. LF-EMF prevented decreased RPP in I/R hearts, while having no effect on coronary flow. In addition, hearts subjected to I/R exhibited significantly increased LVDP when subjected to LF-EMF. Although TnI and IL-6 levels were increased in I/R hearts, their levels returned to baseline aerobic levels in I/R hearts subjected to LF-EMF. The reduced activity of MMP-2 in I/R hearts was reversed in hearts subjected to LF-EMF. The data presented here indicate that acute exposure to LF-EMF protects mechanical function of I/R hearts and reduces I/R injury.
AuthorsDariusz Bialy, Magdalena Wawrzynska, Iwona Bil-Lula, Anna Krzywonos-Zawadzka, Mieczyslaw Wozniak, Virgilio J J Cadete, Grzegorz Sawicki
JournalBioMed research international (Biomed Res Int) Vol. 2015 Pg. 396593 ( 2015) ISSN: 2314-6141 [Electronic] United States
PMID25961016 (Publication Type: Journal Article)
Chemical References
  • Interleukin-6
  • Reactive Oxygen Species
  • Troponin I
  • Matrix Metalloproteinase 2
Topics
  • Animals
  • Coronary Circulation (radiation effects)
  • Electromagnetic Fields
  • Humans
  • Interleukin-6 (metabolism)
  • Matrix Metalloproteinase 2 (metabolism)
  • Myocardial Contraction (physiology, radiation effects)
  • Myocardial Reperfusion Injury (metabolism, physiopathology, therapy)
  • Myocardium (pathology)
  • Organ Culture Techniques
  • Rats
  • Reactive Oxygen Species (metabolism)
  • Troponin I (metabolism)

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