Abstract | BACKGROUND: METHODS: Male Wistar rats were subjected to a full-thickness burn injury comprising 40% of the total body surface area and were randomized to receive apelin, N(G)-methyl- L-arginine acetate salt ( L-NMMA), and apelin plus treatments with L-NMMA. The following outcome measurements were assessed: apelin/APJ mRNA expression in white adipose tissue (WAT) and muscles, plasma apelin level, and activation of the NLRP3 inflammasome in WAT, Interleukin-1 β, interleukin-6, tumor necrosis factor-α, and monocyte chemoattractant protein-1 levels in plasma, insulin resistance, survival rates, and endothelial nitric oxide synthase phosphorylation in soleus muscles. RESULTS: CONCLUSION:
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Authors | Yunfei Chi, Jiake Chai, Chengfeng Xu, Hongmin Luo, Qinxue Zhang |
Journal | Surgery
(Surgery)
Vol. 157
Issue 6
Pg. 1142-52
(Jun 2015)
ISSN: 1532-7361 [Electronic] United States |
PMID | 25817096
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 Elsevier Inc. All rights reserved. |
Chemical References |
- Apelin
- Apln protein, rat
- Carrier Proteins
- Cytokines
- Cytoskeletal Proteins
- Inflammasomes
- Intercellular Signaling Peptides and Proteins
- NLR Family, Pyrin Domain-Containing 3 Protein
- Nlrp3 protein, rat
- Pyrin
- Reactive Oxygen Species
- Receptors, Cytoplasmic and Nuclear
- Leucine
- NG-Nitroarginine Methyl Ester
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Topics |
- Analysis of Variance
- Animals
- Apelin
- Binding Sites
- Burns
(metabolism, mortality, pathology)
- Carrier Proteins
- Cytokines
(metabolism)
- Cytoskeletal Proteins
(metabolism)
- Disease Models, Animal
- Enzyme-Linked Immunosorbent Assay
- Glucose Tolerance Test
- Inflammasomes
(metabolism)
- Injury Severity Score
- Insulin Resistance
- Intercellular Signaling Peptides and Proteins
(genetics, metabolism)
- Kaplan-Meier Estimate
- Leucine
(metabolism)
- Male
- NG-Nitroarginine Methyl Ester
(pharmacology)
- NLR Family, Pyrin Domain-Containing 3 Protein
- Pyrin
- Random Allocation
- Rats
- Rats, Wistar
- Reactive Oxygen Species
(metabolism)
- Real-Time Polymerase Chain Reaction
(methods)
- Receptors, Cytoplasmic and Nuclear
(genetics, metabolism)
- Sensitivity and Specificity
- Statistics, Nonparametric
- Survival Rate
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