Determining the association between adipokine expression in multiple tissues and phenotypic features of non-alcoholic fatty liver disease in obesity.
Abstract | OBJECTIVES: METHODS: We enrolled 93 severely obese individuals with NAFLD, varying from simple steatosis to severe non- alcoholic steatohepatitis. Their expression of 48 adipokines in the liver, visceral and subcutaneous adipose tissue (SAT) was correlated to their phenotypic features of NAFLD. We further determined whether the correlations were tissue specific and/or independent of covariates, including age, sex, obesity, insulin resistance and type 2 diabetes (T2D). RESULTS: CONCLUSIONS: Our results suggest that in obese individuals, VAT-derived leptin and chemerin, and hepatic expression of TNF, IGF1, IL1RN and PAI-1 are involved in the development of NAFLD features. Further, functional studies are warranted to establish a causal relationship.
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Authors | M G M Wolfs, N Gruben, S S Rensen, F J Verdam, J W Greve, A Driessen, C Wijmenga, W A Buurman, L Franke, L Scheja, D P Y Koonen, R Shiri-Sverdlov, T W van Haeften, M H Hofker, J Fu |
Journal | Nutrition & diabetes
(Nutr Diabetes)
Vol. 5
Pg. e146
(Feb 09 2015)
ISSN: 2044-4052 [Print] England |
PMID | 25664838
(Publication Type: Journal Article)
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