Abstract | BACKGROUND: OBJECTIVE: METHODS: Three-hour hyperinsulinemic euglycemic clamps were performed in 16 patients with moderate to severe, untreated psoriasis and 16 matched control subjects. RESULTS: The 2 groups were similar with regard to age, gender, body mass index, body composition, physical activity, fasting plasma glucose, and glycosylated hemoglobin. Mean ± SEM psoriasis duration was 23 ± 3 years and Psoriasis Area and Severity Index score was 12.7 ± 1.4. Patients with psoriasis exhibited reduced insulin sensitivity compared with control subjects (median M-value 4.5 [range 1.6-14.0] vs 7.4 [range 2.1-10.8] mg/kg/min, P = .046). There were no differences between groups in plasma glucose, insulin, C-peptide, and glucagon during the clamp. LIMITATIONS: The classic hyperinsulinemic euglycemic clamp technique does not allow assessment of endogenous glucose production. CONCLUSION: Patients with psoriasis were more insulin resistant compared with healthy control subjects. This supports that psoriasis may be a prediabetic condition.
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Authors | Mette Gyldenløve, Heidi Storgaard, Jens J Holst, Tina Vilsbøll, Filip K Knop, Lone Skov |
Journal | Journal of the American Academy of Dermatology
(J Am Acad Dermatol)
Vol. 72
Issue 4
Pg. 599-605
(Apr 2015)
ISSN: 1097-6787 [Electronic] United States |
PMID | 25653028
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Blood Glucose
- C-Peptide
- Insulin
- Glucagon
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Topics |
- Adult
- Anthropometry
- Blood Glucose
(analysis)
- C-Peptide
(analysis)
- Case-Control Studies
- Diabetes Mellitus, Type 2
(epidemiology)
- Female
- Glucagon
(blood)
- Gluconeogenesis
- Glucose Clamp Technique
- Glucose Intolerance
- Humans
- Hyperinsulinism
(blood)
- Inflammation
- Insulin
- Insulin Resistance
- Male
- Middle Aged
- Prediabetic State
(epidemiology, metabolism)
- Psoriasis
(epidemiology, metabolism)
- Risk
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