[A case of intra-arterial infusion chemotherapy in small cell lung cancer with liver metastases].

Abstract

A 53 year old male was admitted with cough, chest pain and bloody sputa for one month. His admission chest radiography revealed a tumor shadow in right hilus. The patient was diagnosed as small cell lung cancer (oat cell type) by transbronchial biopsy. Clinical staging was IIIA and performance status was 1. The patient was treated by combined chemotherapy (CPA, ADM and VCR) for 3 courses and chest irradiation (5,000 rad). After such therapy, the primary site was regressive until 2 months prior to death. One month after irradiation, abdominal CT showed multiple liver metastases. Though CDDP 100 mg/body and etoposide 100 mg/body X5 were administered systemically, improvement of metastases of the liver was not revealed by abdominal CT. However, after hepatic arterial infusion of ADM (10 mg/body) suspended in a lipiodol (3 ml/body) and CDDP (100 mg/body) was performed, liver metastases were remarkably regressive by abdominal CT. The patient died of a systemic relapse about 14 months after liver involvement.

• Authors: S Fujii, K Nakajima, K Ueno, Y Sugai, M Adachi
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 16 Issue 11 Pg. 3627-30 (Nov 1989) ISSN: 0385-0684 [Print] Japan
• PMID: 2554817 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Suspensions
• Etoposide
• Iodized Oil
• Doxorubicin
• Cisplatin

Topics

• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Carcinoma, Small Cell (drug therapy, secondary)
• Cisplatin (administration & dosage)
• Doxorubicin (administration & dosage)
• Etoposide (administration & dosage)
• Hepatic Artery
• Humans
• Infusions, Intra-Arterial
• Iodized Oil (administration & dosage)
• Liver Neoplasms (drug therapy, secondary)
• Lung Neoplasms (drug therapy, pathology)
• Male
• Middle Aged
• Remission Induction
• Suspensions