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Etoposide (VP 16)

A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
Also Known As:
VP 16; Eposide; Lastet; Toposar; Vepesid; Celltop; Eposin; Eto-GRY; Etomedac; Etopos; Etoposide Pierre Fabre; Etoposide Teva; Etoposide, (5S)-Isomer; Etoposide, (5a alpha)-Isomer; Etoposide, (5a alpha,9 alpha)-Isomer; Etoposide, alpha-D-Glucopyranosyl Isomer; Etoposido Ferrer Farma; Exitop; NSC-141540; Onkoposid; Riboposid; VP 16-213; VP-16; Vépéside-Sandoz; Eto GRY; Etoposide, alpha D Glucopyranosyl Isomer; NSC 141540; NSC141540; Teva, Etoposide; VP 16 213; VP 16213; VP16; Vépéside Sandoz; alpha-D-Glucopyranosyl Isomer Etoposide; Demethyl Epipodophyllotoxin Ethylidine Glucoside; Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 9-((4,6-O-ethylidene-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R-(5alpha,5abeta,8aalpha,9beta(R*)))-
Networked: 10706 relevant articles (1113 outcomes, 2387 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1. Engert, Andreas: 19 articles (06/2021 - 01/2002)
2. Diehl, Volker: 16 articles (06/2021 - 01/2002)
3. Wilson, Wyndham H: 16 articles (01/2020 - 02/2002)
4. Daugaard, Gedske: 15 articles (11/2022 - 04/2006)
5. Einhorn, Lawrence H: 14 articles (10/2020 - 04/2002)
6. Pfreundschuh, Michael: 14 articles (01/2019 - 01/2002)
7. Schmitz, Norbert: 13 articles (04/2021 - 06/2002)
8. Fukui, Iwao: 13 articles (01/2021 - 07/2002)
9. Shields, Carol L: 13 articles (01/2020 - 04/2002)
10. Steinberg, Seth M: 13 articles (01/2020 - 04/2002)

Related Diseases

1. Neoplasms (Cancer)
2. Small Cell Lung Carcinoma (Small Cell Lung Cancer)
3. Lymphoma (Lymphomas)
4. Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
5. Germ Cell and Embryonal Neoplasms (Germ Cell Tumor)

Related Drugs and Biologics

1. Cisplatin (Platino)
2. Cyclophosphamide (Cytoxan)
3. Carboplatin (JM8)
4. Doxorubicin (Adriamycin)
5. Ifosfamide
6. Vincristine (Oncovin)
7. Cytarabine (Cytosar-U)
8. Bleomycin (Blenoxane)
9. Platinum
10. Prednisone (Sone)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Therapeutics
3. Combination Drug Therapy (Combination Chemotherapy)
4. Radiotherapy
5. Stem Cell Transplantation