Abstract | OBJECTIVE: This study examined whether the occurrence of late neck metastasis in early tongue squamous cell carcinoma can be predicted by evaluating HMGB1 (high mobility group box 1) expression in the primary lesion. METHODS: A case-control study was conducted. The cases comprised 10 patients with late neck metastasis. The controls consisted of 16 patients without recurrence. All were examined immunohistochemically for HMGB1 protein expression. The odds ratio for late neck metastasis in relation to HMGB1 was estimated. RESULTS: RESULTS for HMGB1 were dichotomised into positive staining scores (score, 5-7) and negative scores (0-4). Six cases (60 per cent) and four controls (25 per cent) were HMGB1-positive. Although no significant result was seen, compared with HMGB1-negative patients the odds ratio for late neck metastasis in HMGB1-positive patients was 3.8 (95 per cent confidence interval, 0.6-26.5) after adjusting for other factors. CONCLUSION:
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Authors | H Hanakawa, Y Orita, Y Sato, M Takeuchi, S Takao, K Ohno, T Kohno, N Iwaki, H Marunaka, R Tamamura, M Nishibori, H Nagatsuka, K Nishizaki, T Yoshino |
Journal | The Journal of laryngology and otology
(J Laryngol Otol)
Vol. 128
Issue 10
Pg. 926-31
(Oct 2014)
ISSN: 1748-5460 [Electronic] England |
PMID | 25230256
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Squamous Cell
(genetics, metabolism, pathology)
- Case-Control Studies
- Female
- HMGB1 Protein
(biosynthesis, genetics)
- Humans
- Immunohistochemistry
- Lymph Nodes
(pathology)
- Lymphatic Metastasis
- Male
- Middle Aged
- Tongue Neoplasms
(genetics, metabolism, pathology)
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