It has been revealed that
atherosclerosis and
periodontal disease may have a common mechanism of "chronic
inflammation". Several reports have indicated that periodontal
infection is related to
atherosclerosis, but none have yet reported such an investigation through the cooperation of local clinics. This study was performed in local Japanese clinics to examine the relationship between
periodontal disease and
atherosclerosis under collaborative medical and
dental care. A pilot multicenter cross-sectional study was conducted on 37 medical patients with lifestyle-related diseases under consultation in participating medical clinics, and 79 periodontal patients not undergoing medical treatment but who were seen by participating dental clinics. Systemic examination and periodontal examination were performed at baseline, and the relationships between periodontal and
atherosclerosis-related
clinical markers were analyzed. There was a positive correlation between
LDL-C level and plasma
IgG antibody titer to Porphyromonas gingivalis. According to the analysis under adjusted age, at a cut-off value of 5.04 for plasma
IgG titer to Porphyromonas gingivalis, the
IgG titer was significantly correlated with the level of
low-density lipoprotein cholesterol (
LDL-C). This study suggested that
infection with periodontal bacteria (Porphyromonas gingivalis) is associated with the progression of
atherosclerosis. Plasma
IgG titer to Porphyromonas gingivalis may be useful as the clinical risk marker for
atherosclerosis related to
periodontal disease. Moreover, the application of the blood examination as a medical check may lead to the development of collaborative medical and
dental care within the local medical clinical system for the purpose of preventing the lifestyle-related disease.