Correlation of clinicopathologic parameters and immunohistochemical features of triple-negative invasive lobular carcinoma.
Abstract | PURPOSE: MATERIALS AND METHODS: Clinicopathologic parameters and immunohistochemical stains for ER, PR, E-cadherin, HER2, MIB1, and fluorescent in situ hybridization for HER2 of 255 ILC cases were retrieved. In addition, immunohistochemical analysis was performed for p53, c-kit, vimentin, p16, cyclinD1, and BCL2 on 78 cases where 12 were TNC cases and 66 were non-TNC cases. RESULTS: Of the 255 ILC cases, 218 (85.5%) were classic and 37 (14.5%) were pleomorphic. Seventy-seven (30.1%) cases showed axillary lymph node metastasis. There were 14 of the 255 TNC cases (5.49%) that showed higher incidence in the elderly patients. Six of the 37 (16.21%) cases were pleomorphic and 8 of the 218 (3.7%) cases were classic. Positivity for vimentin was seen in 8 of the 12 cases (67.7%), CK 5 in 3 of the 12 (25%) cases, p16 in 11 of the 12 (91.6%) cases, p53 in 8 of the 12 (66.7%) cases, c-kit in 6 of the 12 (50%) cases, and cyclinD1 in 6 of the 12 cases (50%) indicating basal-like phenotype in 3 cases and nonbasal-like phenotype in 9 cases. There was no statistical significance in lymph node metastasis, tumor recurrence, and distant metastasis between TNC and non-TNC. CONCLUSIONS: TNLC showed distinct clinicopathologic features such as more frequently seen in the elderly, pleomorphic, larger tumor size, increased expression of vimentin, CK 5, p16, p53, and c-kit. Not all cases showed basal-like phenotype. TNLC is less frequently seen as compared with TNC in invasive ductal carcinoma.
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Authors | Aparna Harbhajanka, Ihab Lamzabi, Rohit I Singh, Ritu Ghai, Vijaya B Reddy, Pincas Bitterman, Paolo Gattuso |
Journal | Applied immunohistochemistry & molecular morphology : AIMM
(Appl Immunohistochem Mol Morphol)
Vol. 22
Issue 6
Pg. e18-26
(Jul 2014)
ISSN: 1533-4058 [Electronic] United States |
PMID | 25003839
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Breast Neoplasms
(metabolism, pathology)
- Carcinoma, Lobular
(metabolism, pathology)
- Female
- Humans
- Immunohistochemistry
- Lymphatic Metastasis
- Neoplasm Invasiveness
- Neoplasm Proteins
(metabolism)
- Retrospective Studies
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