Abstract | BACKGROUND: OBJECTIVE: To investigate the utility of plasma CTGF level as a surrogate biomarker in asthma. METHODS: Plasma CTGF levels were measured in 67 patients with stable asthma and 81 healthy volunteers, using the subtraction method. We evaluated correlations between plasma CTGF levels and clinical and physiologic parameters in patients with asthma. RESULTS: Plasma CTGF levels were higher in patients with asthma than in healthy volunteers. Asthmatic patients with a percentage of predicted forced expiratory volume in 1 second (FEV1) less than 80% had significantly higher levels of plasma CTGF than those with a percentage of predicted FEV1 of 80% or more. In patients with asthma, plasma CTGF levels had significantly negative correlations with forced vital capacity (FVC), FEV1, percentage of predicted FEV1, FEV1/FVC ratio, forced expiratory flow at 50% of the FVC (FEF50%), percentage of predicted FEF50%, forced expiratory flow at 75% of the FVC (FEF75%), and percentage of predicted FEF75%, parameters that reflect the degree of airway obstruction. Plasma CTGF levels were negatively correlated with Asthma Control Test scores, a patient-based index of clinical control of asthma. CONCLUSION: TRIAL REGISTRATION: umin.ac.jp/ctr Identifier: UMIN000013081.
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Authors | Masato Kato, Tomoyuki Fujisawa, Dai Hashimoto, Masato Kono, Noriyuki Enomoto, Yutaro Nakamura, Naoki Inui, Etsuko Hamada, Osamu Miyazaki, Syunsuke Kurashita, Masato Maekawa, Takafumi Suda |
Journal | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
(Ann Allergy Asthma Immunol)
Vol. 113
Issue 3
Pg. 295-300
(Sep 2014)
ISSN: 1534-4436 [Electronic] United States |
PMID | 24973271
(Publication Type: Journal Article)
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Copyright | Copyright © 2014 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers
- Connective Tissue Growth Factor
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Topics |
- Aged
- Airway Obstruction
(diagnosis, etiology)
- Asthma
(blood, complications)
- Biomarkers
(blood)
- Case-Control Studies
- Connective Tissue Growth Factor
(blood)
- Female
- Humans
- Male
- Middle Aged
- Respiratory Function Tests
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