Abstract | BACKGROUND: METHODS: RESULTS: Fifteen and a half hours following combined trauma, hepatic cytokine expression and liver damage were significantly increased in animals with normothermia compared with the respective sham group. Hypothermia, however, resulted in a fivefold reduced hepatic expression of IL-8 (mean ± SE, 2.4 ± 1.3; p = 0.01) when compared with the normothermic trauma group (IL-8, 12.8 ± 4.7). Accordingly, granulocyte infiltration and a histologic, semiquantitative score for liver injury were significantly higher in the normothermic trauma group. Serum AST levels raised significantly after trauma and normothermia compared with the respective sham group, while AST levels showed no difference from the sham groups in the hypothermic trauma group. In contrast, neither trauma nor hypothermia influenced the expression of IL-6 and IL-8 and tissue injury in the kidney. CONCLUSION:
Therapeutic hypothermia seems to attenuate the hepatic inflammatory response and the associated liver injury after severe trauma. Therefore, induced hypothermia might represent a potential therapeutic strategy to avoid posttraumatic organ dysfunction.
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Authors | Matthias Fröhlich, Frank Hildebrand, Matthias Weuster, Philipp Mommsen, Juliane Mohr, Ingo Witte, Pierre Raeven, Steffen Ruchholtz, Sascha Flohé, Martijn van Griensven, Hans-Christoph Pape, Roman Pfeifer |
Journal | The journal of trauma and acute care surgery
(J Trauma Acute Care Surg)
Vol. 76
Issue 6
Pg. 1425-32
(Jun 2014)
ISSN: 2163-0763 [Electronic] United States |
PMID | 24854311
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Cytokines
(biosynthesis, genetics)
- DNA
(genetics)
- Disease Models, Animal
- Gene Expression Regulation
- Granulocytes
(pathology)
- Hypothermia, Induced
(methods)
- Inflammation
(diagnosis, etiology, metabolism)
- Liver
(metabolism, pathology)
- Male
- Multiple Trauma
(complications, metabolism, therapy)
- Real-Time Polymerase Chain Reaction
- Swine
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