Acrolein detection: potential theranostic utility in multiple sclerosis and spinal cord injury.

Abstract

Oxidative stress has been implicated as a major pathological process underlying CNS disease and trauma. More specifically, acrolein, an unsaturated aldehyde, produced by way of lipid peroxidation, has been shown to play a crucial role in initiating and perpetuating detrimental effects associated with multiple sclerosis and spinal cord injury. In light of these findings, quantification of acrolein levels both systemically and locally could allow for the use of acrolein as a biomarker to aid in diagnosis and guide treatment regimens. The three main approaches currently available are acrolein derivatization followed by LC/GC-MS, application of an acrolein antibody and subsequent immunoblotting, and the 3-hydroxypropylmercapturic acid-based method. Of these three strategies, the 3-hydroxypropylmercapturic acid-based method is the least invasive allowing for rapid translation of acrolein detection into a clinical setting.

• Authors: Melissa Tully, Lingxing Zheng, Riyi Shi
• Journal: Expert review of neurotherapeutics (Expert Rev Neurother) Vol. 14 Issue 6 Pg. 679-85 (Jun 2014) ISSN: 1744-8360 [Electronic] England
• PMID: 24831349 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Acrolein

Topics

• Acrolein (analysis)
• Humans
• Lipid Peroxidation
• Multiple Sclerosis (diagnosis, therapy)
• Oxidative Stress
• Spinal Cord Injuries (diagnosis, therapy)