Abstract | BACKGROUND: STUDY DESIGN: Cross-sectional prospectively recruited cohort. SETTING: Academic pediatric sleep program. METHODS: Two hundred twenty-six children (mean age: 7.0 ± 2.1 y) underwent overnight polysomnographic evaluation and a fasting blood draw the morning after the sleep study. In addition to lipid profile, homeostasis model assessment of insulin resistance (HOMA-IR) and high-sensitivity C-reactive protein ( hsCRP) assays, monocyte GPR 120 expression, and plasma GPR 120 levels were assessed using quantitative polymerase chain reaction and enzyme-linked immunosorbent assay kits. RESULTS: Obese children and those with OSA had significantly lower GPR 120 monocyte expression and plasma GPR 120 levels. Furthermore, when both obesity and OSA were present, GPR 120 levels were lowest. Linear associations emerged between GPR 120 plasma levels and body mass index (BMI) z score, as well as with apnea-hypopnea index (AHI), saturation of peripheral oxygen (SpO2) nadir, and respiratory arousal index (RAI), with RAI remaining statistically significant when controlling for age, ethnicity, sex, and BMI z score (P < 0.001). Similarly, HOMA-IR was significantly associated with GPR 120 levels, but neither low density lipoprotein nor high density lipoprotein cholesterol or hsCRP levels exhibited significant correlations. CONCLUSIONS:
G protein-coupled receptor 120 (GPR 120) levels are reduced in pediatric OSA and obesity (particularly when both are present) and may play a role in modulating the degree of insulin resistance. The short- and long-term significance of reduced GPR 120 relative to food intake and glycemic deregulation remains undefined.
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Authors | David Gozal, Leila Kheirandish-Gozal, Alba Carreras, Abdelnaby Khalyfa, Eduard Peris |
Journal | Sleep
(Sleep)
Vol. 37
Issue 5
Pg. 935-41
(May 01 2014)
ISSN: 1550-9109 [Electronic] United States |
PMID | 24790272
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- FFAR4 protein, human
- Lipids
- Receptors, G-Protein-Coupled
- C-Reactive Protein
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Topics |
- Body Mass Index
- C-Reactive Protein
(analysis)
- Child
- Cross-Sectional Studies
- Fasting
- Female
- Homeostasis
- Humans
- Insulin Resistance
(physiology)
- Lipids
(blood)
- Male
- Monocytes
(metabolism)
- Obesity
(blood, complications, genetics)
- Polysomnography
- Receptors, G-Protein-Coupled
(blood, genetics)
- Sleep
(physiology)
- Sleep Apnea, Obstructive
(blood, complications, genetics)
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