Abstract | OBJECTIVE: METHODS:
DNA samples from adult schizophrenia or schizoaffective disorder patients of mixed ancestry were genotyped, and weight gain was assessed. We analyzed 16 tag single-nucleotide polymorphisms across the PRKAR2B gene in a Caucasian subset treated either with clozapine or olanzapine (N = 99). Linear regression based on an additive model was performed with the inclusion of relevant covariates. RESULTS: Normalized per cent weight change was analyzed, revealing that patients with the minor allele at rs9656135 had a mean weight increase of 4.1%, whereas patients without this allele had an increase of 3.4%. This association is not significant after correcting for multiple testing. CONCLUSIONS: Because of limited power, PRKAR2B's role in antipsychotic-induced weight gain is unclear, but biological evidence suggests that PRKAR2B may be involved. Further research in larger sample sizes is warranted.
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Authors | Sarah A Gagliano, Arun K Tiwari, Natalie Freeman, Jeffrey A Lieberman, Herbert Y Meltzer, James L Kennedy, Jo Knight, Daniel J Müller |
Journal | Human psychopharmacology
(Hum Psychopharmacol)
Vol. 29
Issue 4
Pg. 330-5
(Jul 2014)
ISSN: 1099-1077 [Electronic] England |
PMID | 24737441
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 John Wiley & Sons, Ltd. |
Chemical References |
- Antipsychotic Agents
- Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit
- PRKAR2B protein, human
- Benzodiazepines
- Clozapine
- Olanzapine
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Topics |
- Adolescent
- Adult
- Aged
- Alleles
- Antipsychotic Agents
(adverse effects, therapeutic use)
- Benzodiazepines
(adverse effects, therapeutic use)
- Clozapine
(adverse effects, therapeutic use)
- Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit
(genetics)
- Female
- Genetic Predisposition to Disease
- Genotyping Techniques
- Humans
- Linkage Disequilibrium
- Male
- Middle Aged
- Olanzapine
- Polymorphism, Single Nucleotide
- Psychotic Disorders
(drug therapy, genetics)
- Schizophrenia
(drug therapy, genetics)
- Weight Gain
(drug effects, genetics)
- White People
(genetics)
- Young Adult
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