Pulmonary toxicity in mice following exposure to cerium chloride.

Abstract

The widespread application of lanthanoids (Lns) in manufacturing industries has raised occupational and environmental health concerns about the possible increased health risks to humans exposed to Lns in their working and living environments. Numerous studies have shown that exposures to Ln cause pulmonary injury in animals, but very little is known about the molecular mechanisms of the pulmonary inflammation caused by cerium chloride (CeCl3) exposure. In this study, we evaluated the oxidative stress and molecular mechanism underlying with the pulmonary inflammation associated with chronic lung toxicity in mice treated with nasally instilled CeCl3 for 90 consecutive days. Our findings suggest that significant cerium accumulated in the lung, leading the obvious increase of the lung indices, significant increases in inflammatory cells and levels of lactate dehydrogenase, alkaline phosphate, and total protein, overproduction of reactive oxygen species and peroxidation of lipids, reduced antioxidant capacity, and pulmonary inflammation. CeCl3 exposure also activated nuclear factor κB, increased the expression of tumor necrosis factor α, cyclooxygenase-2, heme oxygenase 1, interleukin 2, interleukin 4, interleukin 6, interleukin 8, interleukin 10, interleukin 18, interleukin 1β, and CYP1A1. However, CeCl3 reduced the expression of nuclear factor κB (NF-κB)-inhibiting factor and heat shock protein 70. These findings suggest that the pulmonary inflammation caused by CeCl3 in mice is closely associated with oxidative stress and inflammatory cytokine expression.

• Authors: Jie Hong, Xiaohong Yu, Xiaoyu Pan, Xiaoyang Zhao, Lei Sheng, Xuezi Sang, Anan Lin, Chi Zhang, Yue Zhao, Suxin Gui, Qingqing Sun, Ling Wang, Fashui Hong
• Journal: Biological trace element research (Biol Trace Elem Res) Vol. 159 Issue 1-3 Pg. 269-77 (Jun 2014) ISSN: 1559-0720 [Electronic] United States
• PMID: 24736977 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Interleukin-18
• Interleukin-1beta
• Interleukin-2
• Interleukin-6
• Interleukin-8
• NF-kappa B
• Interleukin-4
• Cerium
• Cytochrome P-450 CYP1A1
• Heme Oxygenase-1
• Cyclooxygenase 2

Topics

• Animals
• Cerium (toxicity)
• Cyclooxygenase 2 (metabolism)
• Cytochrome P-450 CYP1A1 (metabolism)
• Heme Oxygenase-1 (metabolism)
• Interleukin-18 (metabolism)
• Interleukin-1beta (metabolism)
• Interleukin-2 (metabolism)
• Interleukin-4 (metabolism)
• Interleukin-6 (metabolism)
• Interleukin-8 (metabolism)
• Lung (drug effects, metabolism)
• Male
• Mice
• NF-kappa B (metabolism)
• Oxidative Stress (drug effects)
• Rats, Wistar