Abstract | PURPOSES: METHODS: A total of 21 male, adult wistar albino rats were used. The animals were divided into three groups as control, BLM and BLM plus LEF groups (n=7). In BLM group, mice were treated with intratracheal instillation of BLM (2.5 U/kg). Control group received the same volume of saline instead of BLM. In LEF group, in addition to BLM, LEF (10 mg/kg, daily) was administrated by oral gavage. The effect of LEF on pulmonary inflammation and fibrosis was studied by measurements of serum clara cell protein-16 (CC-16), thiobarbituric acid reactive substance levels ( TBARS), superoxide dismutase (SOD) and advanced oxidation protein products ( AOPP) levels and lung tissue contents of IL-6, TNF-α and NF-κB by immunhistochemical examinations. RESULTS: LEF significantly increased the level of CC-16 and decreased the level of AOPP (P=0.042 and P=0.003 respectively). Lung tissue contents of IL-6, TNF-α and NF-κB significantly decreased in LEF group compared to BLM group by immunhistochemical examinations (P<0.001). CONCLUSIONS:
|
Authors | Servet Kayhan, Aygul Guzel, Latif Duran, Serife Tutuncu, Ahmet Guzel, Mithat Gunaydın, Osman Salis, Ali Okuyucu, Mustafa Yasin Selcuk |
Journal | Journal of thoracic disease
(J Thorac Dis)
Vol. 5
Issue 5
Pg. 641-9
(Oct 2013)
ISSN: 2072-1439 [Print] China |
PMID | 24255778
(Publication Type: Journal Article)
|