Abstract | BACKGROUND: MATERIALS AND METHODS: RESULTS: Within 72 h of mechanical ventilation, we observed significantly improved gas exchange (oxygenation and ventilation), lung mechanics (compliance and resistance of the respiratory system), and pulmonary oedema (extra-vascular lung water index) in the surfactant + DOPG group. This favourable clinical effect could be attributed to improved surfactant function, reduced sPLA2 secretion, inhibition of macrophage migration, reduced alveolar epithelial apoptosis, and suppression of amphiregulin and TGF-β1 expression in pulmonary tissues as a prerequisite for fibrous lung repair. CONCLUSIONS: We conclude that surfactant fortified by DOPG preserves lung function, and prevents alveolar epithelial injury and fibrous stimulus by reduction of sPLA2 in a neonatal model of acute respiratory distress syndrome without any relevant discernable side effects. Hence, DOPG supplementation in a neonatal lung exerts important function protecting effects and seems to be justified in cases of overwhelming pulmonary inflammation.
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Authors | Stefanie Preuß, Julia Scheiermann, Sabrina Stadelmann, Friede D Omam, Supandi Winoto-Morbach, Dennis Lex, Philipp von Bismarck, Sabine Adam-Klages, Friederike Knerlich-Lukoschus, Daniela Wesch, Janka Held-Feindt, Stefan Uhlig, Stefan Schütze, Martin F Krause |
Journal | Pulmonary pharmacology & therapeutics
(Pulm Pharmacol Ther)
Vol. 28
Issue 1
Pg. 25-34
(Jun 2014)
ISSN: 1522-9629 [Electronic] England |
PMID | 24140177
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 Elsevier Ltd. All rights reserved. |
Chemical References |
- Phosphatidylglycerols
- Pulmonary Surfactants
- 1,2-dioleoyl-sn-glycero-3-phosphoglycerol
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Topics |
- Animals
- Animals, Newborn
- Apoptosis
(drug effects)
- Disease Models, Animal
- Epithelial Cells
(drug effects, pathology)
- Female
- Macrophages, Alveolar
(drug effects, metabolism)
- Male
- Phosphatidylglycerols
(pharmacology)
- Pulmonary Alveoli
(cytology, drug effects, pathology)
- Pulmonary Edema
(prevention & control)
- Pulmonary Fibrosis
(pathology, prevention & control)
- Pulmonary Surfactants
(pharmacology)
- Respiration, Artificial
- Respiratory Distress Syndrome, Newborn
(prevention & control)
- Swine
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