Abstract | PURPOSE: METHODS: RESULTS: Vitreous fluid levels of vascular endothelial growth factor ( VEGF), soluble VEGF receptor 2 (sVEGFR-2), soluble intercellular adhesion molecule 1 (sICAM-1), interleukin 6 (IL-6), monocyte chemotactic protein 1 (MCP-1), and pentraxin 3 (PTX3) were significantly higher in CRVO patients than in macular hole patients. Vitreous fluid levels of VEGF, sICAM-1, IL-6, MCP-1, and PTX3 were significantly correlated with the retinal thickness at the central fovea. There were significant correlations between the vitreous fluid level of VEGF and the levels of sICAM-1, IL-6, and MCP-1 in the CRVO patients. There was also a significant correlation between sVEGFR-2 and PTX3 but not between VEGF and PTX3. CONCLUSION: These findings suggest the importance of VEGF, its signal transduction pathways, and the cytokine network and may be useful for understanding the mechanism of macular edema in CRVO and developing new treatments.
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Authors | Hidetaka Noma, Tatsuya Mimura, Hidetaka Masahara, Katsunori Shimada |
Journal | Retina (Philadelphia, Pa.)
(Retina)
Vol. 34
Issue 2
Pg. 352-9
(Feb 2014)
ISSN: 1539-2864 [Electronic] United States |
PMID | 23842103
(Publication Type: Journal Article)
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Chemical References |
- Acute-Phase Proteins
- Chemokine CCL2
- Cytokines
- IL6 protein, human
- Interleukin-6
- Serum Amyloid P-Component
- VEGFA protein, human
- Vascular Endothelial Growth Factor A
- Intercellular Adhesion Molecule-1
- PTX3 protein
- C-Reactive Protein
- Vascular Endothelial Growth Factor Receptor-2
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Topics |
- Acute-Phase Proteins
(metabolism)
- Aged
- C-Reactive Protein
(metabolism)
- Chemokine CCL2
(metabolism)
- Cytokines
(metabolism)
- Enzyme-Linked Immunosorbent Assay
- Female
- Fluorescein Angiography
- Humans
- Intercellular Adhesion Molecule-1
(metabolism)
- Interleukin-6
(metabolism)
- Macular Edema
(diagnosis, metabolism)
- Male
- Retinal Vein Occlusion
(diagnosis, metabolism)
- Serum Amyloid P-Component
(metabolism)
- Tomography, Optical Coherence
- Vascular Endothelial Growth Factor A
(metabolism)
- Vascular Endothelial Growth Factor Receptor-2
(metabolism)
- Vitrectomy
- Vitreous Body
(metabolism)
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