To compare oxidative stress (OS)
biomarkers and
antioxidant capacity of plasma (ACP) between dcSSc (
diffuse cutaneous systemic sclerosis) and healthy Mexicans and their possible relationship with
autoantibodies,
C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and
uric acid (UA). We included 28 dcSSc and 28 healthy individuals. Patients were grouped in early and late dcSSc and were excluded if they had
infections,
neoplasias, comorbidity, or
antioxidant treatment. Lipoperoxidation products (
malondialdehyde),
protein oxidation products (carbonyls, dityrosines), ACP, CRP, ESR, and UA were investigated. Age was 47.5 ± 10 in dcSSc versus 48 ± 7 years in controls. In dcSSc, OS was higher and ACP was decreased versus controls (p < 0.001). OS was similar in early and late dcSSc. Anti-Scl-70 (anti-
topoisomerase I) was associated with a higher OS (p < 0.05). Eight dcSSc patients had
hyperuricemia (28.5 %). A significant correlation between UA and
malondialdehyde, dityrosines and carbonyls levels (r = 0.52, r = 0.78 and r = 0.69, p < 0.01) respectively, was found in dcSSc group. A high level of ESR was present in 71 % and CRP in 40 % of dcSSc patients. Mexican dcSSc patients had elevated
lipid/
protein OS with respect to healthy controls. These OS
biomarkers have direct correlation with UA levels. ESR and CRP were elevated in a great number of dcSSc patients. These
biochemical markers suggest that dcSSc patients have a continuous stimulus for endothelial dysfunction and accelerated
atherogenesis.