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Type I DNA Topoisomerases (Topoisomerase I)

DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. DNA Topoisomerases, Type I enzymes reduce the topological stress in the DNA structure by relaxing the superhelical turns and knotted rings in the DNA helix.
Also Known As:
Topoisomerase I; DNA Topoisomerase; DNA Topoisomerases, Type I; DNA Nicking-Closing Proteins; DNA Relaxing Enzymes; DNA Type 1 Topoisomerase; DNA Untwisting Enzymes; DNA Untwisting Proteins; Type I DNA Topoisomerase; III beta, Topoisomerase; III, DNA Topoisomerase; III, Topo; III, Topoisomerase; IIIalpha, TOPO; IIIalpha, Topoisomerase; IIIbeta, Topoisomerase; Topoisomerase III, DNA; Topoisomerase, TOP3; beta, Topoisomerase III; DNA Nicking-Closing Protein; DNA Relaxing Enzyme; DNA Relaxing Protein; DNA Topoisomerase I; DNA Topoisomerase III; DNA Topoisomerase III alpha; DNA Topoisomerase III beta; DNA Untwisting Enzyme; DNA Untwisting Protein; TOP3 Topoisomerase; TOP3alpha; TOPO IIIalpha; Topo III; Topoisomerase III; Topoisomerase III beta; Topoisomerase IIIalpha; Topoisomerase IIIbeta
Networked: 1588 relevant articles (54 outcomes, 190 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Pommier, Yves: 53 articles (12/2022 - 01/2002)
2. Kwon, Youngjoo: 18 articles (03/2022 - 01/2010)
3. Lee, Eung-Seok: 18 articles (10/2018 - 07/2007)
4. Karki, Radha: 13 articles (05/2016 - 07/2007)
5. Bailly, Christian: 13 articles (02/2015 - 11/2002)
6. Na, Younghwa: 12 articles (11/2016 - 07/2007)
7. Cushman, Mark: 11 articles (12/2021 - 01/2002)
8. Agama, Keli: 10 articles (12/2022 - 12/2006)
9. Thapa, Pritam: 10 articles (09/2014 - 07/2007)
10. Senécal, Jean-Luc: 9 articles (06/2020 - 10/2004)

Related Diseases

1. Neoplasms (Cancer)
2. Colorectal Neoplasms (Colorectal Cancer)
3. Poisoning
4. Leukemia
5. Small Cell Lung Carcinoma (Small Cell Lung Cancer)

Related Drugs and Biologics

1. Irinotecan (Camptosar)
2. DNA (Deoxyribonucleic Acid)
3. Topotecan (Hycamtin)
4. Camptothecin
5. Enzymes
6. Proteins (Proteins, Gene)
7. Poisons
8. Type II DNA Topoisomerases (Topoisomerase II)
9. Antineoplastic Agents (Antineoplastics)
10. 2- cyclohexylidenhydrazo- 4- phenyl- thiazole

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Therapeutics
3. Adjuvant Chemotherapy
4. Neoadjuvant Therapy
5. Combination Drug Therapy (Combination Chemotherapy)