Leptin and its association with somatic depressive symptoms in patients with the metabolic syndrome.

Abstract

BACKGROUND:

This study aimed to determine the association between circulating leptin levels and total depressive symptoms as well as depressive symptom dimensions (cognitive and somatic) after controlling for important confounding factors.

METHODS:

The study sample was comprised of 135 participants with the metabolic syndrome. Depressive symptoms were measured using the Beck Depression Inventory-II. Leptin was measured using a leptin-specific enzyme immunoassay. Inflammation was assessed using C-reactive protein and interleukin-6 levels.

RESULTS:

Leptin was significantly associated with somatic depressive symptoms (β = 0.33, P = 0.018), but not total depressive symptoms (β = 0.27, P = 0.067) or cognitive depressive symptoms (β = 0.21, P = 0.182), after controlling for age, gender, body mass index, and insulin resistance. Further adjustment for C-reactive protein and interleukin-6 levels did not alter the relationship (β = 0.32, P = 0.023) between circulating leptin levels and somatic depressive symptoms.

CONCLUSIONS:

Leptin is independently associated with somatic depressive symptoms in patients with the metabolic syndrome.

• Authors: Diana A Chirinos, Ronald Goldberg, Marc Gellman, Armando J Mendez, Miriam Gutt, Judith R McCalla, Maria M Llabre, Neil Schneiderman
• Journal: Annals of behavioral medicine : a publication of the Society of Behavioral Medicine (Ann Behav Med) Vol. 46 Issue 1 Pg. 31-9 (Aug 2013) ISSN: 1532-4796 [Electronic] England
• PMID: 23436275 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Interleukin-6
• Leptin
• C-Reactive Protein

Topics

• Adult
• Body Mass Index
• C-Reactive Protein (metabolism)
• Depression (blood, complications, diagnosis)
• Female
• Humans
• Inflammation (blood)
• Insulin Resistance (physiology)
• Interleukin-6 (blood)
• Leptin (blood)
• Male
• Metabolic Syndrome (blood, complications)
• Middle Aged
• Psychiatric Status Rating Scales
• Risk Factors