Peripheral neuropathy in cystic fibrosis: a prevalence study.

Abstract

BACKGROUND:

Information on peripheral neuropathy in children with cystic fibrosis is scanty. The etiology can be multifactorial (micronutrient deficiency, chronic hypoxia, impaired glucose tolerance, immunological, vasculopathic, critical illness).

METHODS:

Forty five cystic fibrosis children aged 1-18 years on vitamin E supplementation for at least 6 months underwent detailed neurological examination, serum vitamin E, vitamin B12, folate, copper levels and detailed nerve conduction studies.

RESULTS:

The mean age of the study population was 8.35 years (±4.9 years) with 62.2% being males. Overall 22 out of 45 (48.88%,CI: 33.7-64.2) had electrophysiological evidence of peripheral neuropathy which was predominantly axonal (86.4%), sensory (50%), and polyneuropathy (95.45%). There was no significant association between status of serum micronutrients and electrophysiological evidence of peripheral neuropathy.

CONCLUSION:

Patients with cystic fibrosis have electrophysiological evidence of peripheral neuropathy (predominantly axonal, sensory and polyneuropathy). There is significant association of higher chronological age with occurrence of peripheral neuropathy.

• Authors: Biswaroop Chakrabarty, S K Kabra, Sheffali Gulati, G S Toteja, Rakesh Lodha, Madhulika Kabra, R M Pandey, Achal Srivastava
• Journal: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society (J Cyst Fibros) Vol. 12 Issue 6 Pg. 754-60 (Dec 2013) ISSN: 1873-5010 [Electronic] Netherlands
• PMID: 23391476 (Publication Type: Journal Article)
• Copyright: Copyright © 2013 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

Chemical References

• Vitamin E
• Copper
• Folic Acid
• Vitamin B 12

Topics

• Adolescent
• Child
• Child, Preschool
• Comorbidity
• Copper (blood)
• Cystic Fibrosis (blood, epidemiology)
• Female
• Folic Acid (blood)
• Humans
• Infant
• Male
• Peripheral Nervous System Diseases (blood, epidemiology)
• Prevalence
• Vitamin B 12 (blood)
• Vitamin E (blood)