Critical Illness (Critically Ill)

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8682 relevant articles (448 outcomes, 1157 trials/studies) found for this Disease

Description: A disease or state in which death is possible or imminent.

Also Known As:

Critically Ill; Critical Illnesses; Illness, Critical; Illnesses, Critical

Relationship Network

Disease Context: Research Results

Signs and Symptoms Pathological Conditions

Pathologic Processes: 2442

Disease Attributes

Critical Illness: 8682

Related Diseases

1.	Sepsis (Septicemia)
2.	Infection
3.	Hemorrhage
4.	Hyperglycemia
5.	Acute Kidney Failure (Acute Renal Failure)

Experts

1.	Van den Berghe, Greet: 35 articles (09/2008 - 05/2002)
2.	Wouters, Pieter J: 15 articles (03/2008 - 02/2003)
3.	Corwin, Howard L: 14 articles (09/2008 - 12/2002)
4.	Vanhorebeek, Ilse: 10 articles (09/2008 - 01/2005)
5.	Heyland, Daren K: 10 articles (09/2008 - 11/2002)
6.	Berger, Mette M: 9 articles (09/2008 - 09/2002)
7.	Mesotten, Dieter: 9 articles (09/2008 - 12/2002)
8.	Roberts, I: 9 articles (01/2007 - 01/2000)
9.	Bellomo, Rinaldo: 8 articles (08/2008 - 08/2003)
10.	Langouche, Lies: 8 articles (06/2008 - 01/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Critical Illness:

1.	Insulin (Novolin)FDA Link 06/01/2007 - "Recent clinical trials have shown a significant reduction in morbidity and mortality rates with the use of intensive insulin therapy to maintain strict normoglycemia in critically ill patients. " 01/01/2006 - "A significant reduction in morbidity and mortality can be achieved by using intensive insulin therapy to achieve normoglycemia in the critically ill patient. " 03/01/2005 - "Interestingly, intensive insulin therapy in critically ill patients improved morbidity and mortality, but the exact mechanisms by which these beneficial effects are brought about remain unknown. " 08/01/2005 - "Glycemic and nonglycemic effects of insulin: how do they contribute to a better outcome of critical illness?" 03/01/2003 - "In conclusion, intensive insulin therapy exerts a powerful antiinflammatory effect during critical illness which at least partially explains improvement in morbidity and mortality. " Order ALL the reference details at left...
2.	Blood Glucose (Blood Sugar)IBA 01/01/2009 - "INTRODUCTION: Maintaining arterial blood glucose within tight limits is beneficial in critically ill patients. " 09/01/2008 - "Controlling blood glucose concentrations may therefore be beneficial in the critically ill neonatal foal, and this warrants further investigation." 03/01/2004 - "There is increasing evidence that maintenance of normal blood glucose in the perioperative period and during critical illness is beneficial for diabetic and non-diabetic patients. " 01/01/2009 - "Maintaining blood glucose levels between 80 and 110 mg/dL has been shown to improve outcomes such as mortality and infectious complications in critically ill patients, while also decreasing length of hospital stay and healthcare expenditures. " 12/01/2005 - "Early correction and tight control of blood glucose levels was shown to improve outcome in critically ill surgical patients. " Order ALL the reference details at left...
3.	Glutamine (L-Glutamine)FDA Link 01/01/2001 - "Although glutamine status in the critically ill patient can be improved by nutritional means, the most effective way of effecting such supplementation has received little attention. " 11/01/1996 - "We hypothesize that glutamine-enriched TPN may have been beneficial in the hospital course of this critically ill patient and may have influenced the patient's intestinal function and permeability." 09/01/2006 - "BACKGROUND: Glutamine (GLN) has been shown to improve outcome after experimental and clinical models of critical illness. " 03/01/2003 - "Laboratory data have demonstrated numerous benefits of glutamine in experimental models of critical illness, including attenuated proinflammatory cytokine expression, improved gut barrier function, enhanced ability to mount a stress response, improved immune cell function, and decreased mortality. " 08/01/2009 - "Current evidence and ongoing trials on the use of glutamine in critically-ill patients and patients undergoing surgery." Order ALL the reference details at left...
4.	Glucose (Dextrose)FDA LinkGeneric 01/01/1980 - "However, the efficacy of this depends on: (1) early nutritional assessment; (2) sequential nutritional assessment as dictated by the clinical condition of the patient; (3) careful estimation of requirements based on calculated energy expenditure and use of the "stress-index"; (4) early use of enteral feedings in combination with peripheral and central intravenous routes, especially with the use of "feeding modules" to provide patient's specific concentrated diet; (5) use of intravenous fat as an isotonic supplement to dextrose in the presence of carbohydrate intolerance; (6) avoid overfeeding as rigorously as underfeeding; (7) continued clinical trials to determine optimal nutritional/metabolic support of the critically ill." 03/01/2005 - "CONCLUSION: Implementing a computerized version of a guideline significantly improved timeliness of measurements and glucose level regulation for critically ill patients compared with implementing a paper-based version of the guideline." 01/01/2009 - "CONCLUSIONS: In this feasibility study the eMPC algorithm provided similar, effective and safe tight glucose control over 72 h in critically ill patients in two different ICUs. " 09/01/2009 - "Differences in outcome between the NICE-SUGAR and Leuven trials: biological mechanisms of intensive glucose control in critically ill patients." 01/01/2009 - "The aim of this study was to quantify glucose absorption and the relationships between GE, glucose absorption and glycaemia in critically ill patients. " Order ALL the reference details at left...
5.	Cimetidine (Biomet)FDA LinkGeneric 11/01/1990 - "Clinical studies with rapidly administered intravenous cimetidine in critically ill patients have demonstrated a depression in blood pressure in up to 75 percent of patients. " 12/18/1987 - "However, recent studies with primed continuous infusion of cimetidine in critically ill patients have demonstrated that consistent elevation of gastric pH to 4.0 may be attained with this regimen. " 09/01/1990 - "Continuous v intermittent cimetidine infusion in critically ill hospitalized patients: role of TPN admixture as drug vehicle." 10/01/1989 - "The Authors suggest that only critically ill patients require prophylactic use of cimetidine." 01/01/1989 - "Effect of a 2 g cimetidine infusion on 24-h intragastric pH in critically ill patients." Order ALL the reference details at left...
6.	OxygenIBA 07/01/1993 - "When serial measurements of oxygen delivery, oxygen consumption, and the oxygen extraction ratio follow each therapeutic intervention that is directed at increasing oxygen delivery, the survival rate of critically ill patients is significantly improved." 12/01/2002 - "Although these devices have improved our understanding of pathophysiological mechanisms of critical illness, at a clinical level titrating oxygen therapy to tissue oxygen tensions has only been shown to be useful in patients with impaired wound healing. " 06/16/1994 - "Elevation of systemic oxygen delivery and consumption has been associated with an improved outcome in critically ill patients. " 02/01/1986 - "Measurement of mixed venous oxygen saturation (SvO2) may be helpful in the care of critically ill patients. " 11/01/2009 - "Further study will examine the mechanism of adherence and the impact it has on microcirculatory flow and oxygen delivery in the critically ill host." Order ALL the reference details at left...
7.	ErythropoietinIBA 06/01/1998 - "[Efficacy of early erythropoietin use in critically ill, very-low-birthweight premature newborn infants: controlled clinical trial]" 09/01/2006 - "Efficacy of recombinant human erythropoietin in critically ill patients admitted to a long-term acute care facility: a randomized, double-blind, placebo-controlled trial." 10/05/2005 - "INTRODUCTION: The aim of this study was to assess the efficacy of two dosing schedules of recombinant human erythropoietin (rHuEPO) in increasing haematocrit (Hct) and haemoglobin (Hb) and reducing exposure to allogeneic red blood cell (RBC) transfusion in critically ill patients. " 11/01/1999 - "Efficacy of recombinant human erythropoietin in the critically ill patient: a randomized, double-blind, placebo-controlled trial." 12/11/2002 - "Efficacy of recombinant human erythropoietin in critically ill patients: a randomized controlled trial." Order ALL the reference details at left...
8.	Fluconazole (Zonal)FDA LinkGeneric 01/06/2009 - "Empirical use of fluconazole in critically ill patients: good study, but what was the hold-up?" 01/06/2009 - "Empirical use of fluconazole in critically ill patients: good study, but what was the hold-up?" 09/01/2005 - "Performing a sensitivity analysis and including two additional studies that indirectly examined fluconazole prophylaxis in the critically ill did not change our observations. " 09/01/2006 - "It is believed that this complication of adrenal suppression attributable to fluconazole is underrecognised and it may be prudent to monitor all critically ill patients who are given fluconazole for this complication." 04/01/2006 - "However, our data demonstrate, that at least the fluconazole concentrations desirable on the basis of in vitro susceptibility testing can be reached in critically ill patients on CVVHF in an ICU setting. " Order ALL the reference details at left...
9.	Ranitidine (Zantac)FDA LinkGeneric 05/01/1991 - "These data indicate that continuous infusion of ranitidine is superior to bolus administration in controlling gastric acidity in critically ill patients." 04/01/2001 - "OBJECTIVE: To determine the pharmacokinetics and pharmacodynamics of ranitidine in critically ill children and to design a dosage regimen that achieves a gastric pH > or =4. DESIGN: Prospective, open-label, pharmacokinetic-pharmacodynamic study. " 11/01/1992 - "While case reports of ranitidine CNS-ADRs have appeared, we wanted to study a series of patients, some of whom were critically ill, for the presence of CNS-ADRs and to correlate these with ranitidine pharmacokinetics. " 04/01/2001 - "CONCLUSIONS: The pharmacokinetics of ranitidine in critically ill children are variable. " 04/01/2001 - "Pharmacokinetics and pharmacodynamics of ranitidine in critically ill children." Order ALL the reference details at left...
10.	Erythromycin (Erycette)FDA LinkGeneric 07/01/2005 - "CONCLUSIONS: Treatment with 70 and 200 mg intravenous erythromycin are equally effective in accelerating gastric emptying in the critically ill." 05/01/2001 - "Efficacy of erythromycin for postpyloric placement of feeding tubes in critically ill children: a randomized, double-blind, placebo controlled study." 03/01/2007 - "Further large and methodologically robust studies are needed to ascertain the effectiveness of erythromycin A and other alternative agents in the critically ill." 01/01/2003 - "Intravenous erythromycin facilitates bedside placement of postpyloric feeding tubes in critically ill adults: a double-blind, randomized, placebo-controlled study." 08/01/1995 - "Effect of erythromycin on gastric motility in mechanically ventilated critically ill patients: a double-blind, randomized, placebo-controlled study." Order ALL the reference details at left...

Therapies and Procedures

1.	Enteral Nutrition (Feeding, Tube) 08/01/1995 - "Furthermore, there is increasing evidence, that enteral nutrition provides significant benefits to patients who are critically ill and after major gastrointestinal surgery. " 05/01/1994 - "We demonstrated the safety and efficacy of immediate enteral feeding in patients with major thermal injury, and have found this practice to be applicable to a wide variety of other critically ill patients. " 09/01/2009 - "A new concept of a therapeutic range of energy delivery in the critically ill has emerged implying the need for re-evaluation of energy recommendations and improved delivery of enteral nutrition. " 06/01/2008 - "CONCLUSION: The dual stylet method can be used effectively and safely in critically ill patients as a bedside measure after placement of the spiral distal end nasal-enteral feeding tubes." 07/01/2003 - "OBJECTIVE: To study the utility and efficacy of transpyloric enteral nutrition (TEN) in critically-ill children by analyzing the factors that determine enteral tolerance. " Order ALL the reference details at left...
2.	Artificial Respiration (Mechanical Ventilation) 08/01/2007 - "We evaluated the efficacy of the COMFORT scale in assessing optimal sedation in critically ill children requiring mechanical ventilation. " 08/01/2007 - "The efficacy of the COMFORT scale in assessing optimal sedation in critically ill children requiring mechanical ventilation." 10/01/2003 - "STUDY OBJECTIVES: To compare the diagnostic capability of recently available hand-held echocardiography (HHE) and of conventional transthoracic echocardiography (TTE) used as a gold standard in critically ill patients under mechanical ventilation. " 06/01/2008 - "CONCLUSION: Newer modalities of sedation and mechanical ventilation have not entirely eliminated the discomforts of critical illness; the human aspects of suffering remain. " 11/01/2007 - "CONCLUSIONS: The majority of patients requiring prolonged mechanical ventilation in a respiratory unit after acute critical illness are liberated from mechanical ventilation, survive, and have a steady improvement in the activity of daily living during the first 6 months after discharge. " Order ALL the reference details at left...
3.	Renal Replacement Therapy (Therapies, Renal Replacement) 04/01/2008 - "Small randomized trials give some evidence that an early start of renal replacement therapy may be beneficial in critically ill patients. " 07/01/1998 - "CONCLUSIONS: Continuous veno-venous renal replacement therapies are useful in the treatment of critically ill children. " 05/01/1990 - "Continuous arteriovenous hemodiafiltration is a safe and effective means of renal replacement therapy in the critically ill child. " 07/01/1987 - "CAVH is an effective and safe extracorporal renal replacement therapy system to correct fluid- and electrolyte imbalances in critically ill children. " 10/01/1986 - "Continuous arteriovenous hemofiltration is a safe and effective renal replacement therapy system for critically ill patients. " Order ALL the reference details at left...
4.	Nutritional Support (Artificial Feeding) 05/01/2004 - "SUMMARY OF BACKGROUND DATA: Early nutritional support has been found to be beneficial in critically ill patients. " 04/01/1999 - "RESULTS: The provision of nutritional support supplemented with key nutrients to patients with critical illness resulted in a decrease in infectious complications when compared with patients receiving standard nutritional support and a significant reduction in overall hospital stay. " 06/01/1996 - "Improved nutrition assessment parameters are required to better monitor the response to nutritional support in critically ill patients." 04/01/2000 - "Nasoenteric feeding tubes are a safe and effective means for providing nutritional support to the critically ill patient. " 12/01/2006 - "The acutely ventilated patient that is likely to still be intubated by day three is a classic example of the critically ill patient who has the potential to achieve positive outcomes with nutritional support. " Order ALL the reference details at left...
5.	Intensive Care (Surgical Intensive Care) 01/01/1988 - "Long-term Swan-Ganz monitoring in an intensive care setting may dramatically benefit the critically ill patient with GBS and cardiovascular autonomic dysfunction, and may help to eliminate the residual morbidity and mortality associated with this disease." 01/01/1989 - "It is a major advance in the management of these critically ill patients, as it is carried out at the bedside by the intensive care nursing staff." 01/01/2000 - "Few studies have tried to characterize the efficacy of parenteral support of critically ill infants during short period of intensive care. " 11/01/2007 - "The development of paediatric intensive care has contributed to the improved survival of critically ill children. " 01/01/2009 - "The PRaCTICaL study of nurse led, intensive care follow-up programmes for improving long term outcomes from critical illness: a pragmatic randomised controlled trial." Order ALL the reference details at left...

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