Abstract |
Once established, serum antibody responses against a specific pathogen may last a lifetime. We describe a cohort of four subjects who received smallpox vaccination, and a single subject who received multiple vaccinations, with antibody levels to unrelated antigens monitored for 1-3 years. These immunizations provided the opportunity to determine if infection/vaccination and the resulting toll-like receptor stimulation would alter antigen-specific serological memory to other antigens, including bacterial toxins ( tetanus, diphtheria, and pertussis) and viruses (yellow fever virus, measles, mumps, rubella, Epstein-Barr virus, and varicella-zoster virus). Our results indicate that serum IgG levels are remarkably stable and infection or vaccination are unlikely to increase or decrease pre-existing antigen-specific antibody responses.
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Authors | Ian J Amanna, Erika Hammarlund, Mathew W Lewis, Mark K Slifka |
Journal | Human immunology
(Hum Immunol)
Vol. 73
Issue 11
Pg. 1082-6
(Nov 2012)
ISSN: 1879-1166 [Electronic] United States |
PMID | 22902392
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Antibodies, Viral
- Immunoglobulin G
- Vaccines
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Topics |
- Antibodies, Viral
(blood, immunology)
- Antibody Formation
(immunology)
- Humans
- Immunoglobulin G
(blood, immunology)
- Immunologic Memory
- Infections
(etiology, immunology)
- Vaccination
- Vaccines
(immunology)
- Vaccinia
(immunology)
- Vaccinia virus
(immunology)
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