The role of interleukin-1 in allergy-related disorders.

Abstract

PURPOSE OF REVIEW:

Interleukin-1β (IL-1β) is a potent proinflammatory cytokine, which is involved in many inflammatory conditions including autoinflammatory and allergic disorders. This review provides insights into recent advances of our understanding of the pathogenesis of IL-1β-associated allergy-related disorders.

RECENT FINDINGS:

In autoinflammatory as well as allergic diseases such as contact hypersensitivity, atopic dermatitis and bronchial asthma, dysfunctional inflammasome processing has been demonstrated to account for IL-1β-induced inflammation. IL-1-neutralizing drugs have been shown to completely suppress or markedly reduce inflammatory responses in clinical studies and experimental models of urticarial autoinflammatory diseases as well as common allergic disorders.

SUMMARY:

The recent findings support a crucial role for IL-1β and inflammasome components in a variety of allergy-related disorders.

• Authors: Karoline Krause, Martin Metz, Michael Makris, Torsten Zuberbier, Marcus Maurer
• Journal: Current opinion in allergy and clinical immunology (Curr Opin Allergy Clin Immunol) Vol. 12 Issue 5 Pg. 477-84 (Oct 2012) ISSN: 1473-6322 [Electronic] United States
• PMID: 22885885 (Publication Type: Journal Article, Review)

Chemical References

• Inflammasomes
• Interleukin-1beta

Topics

• Animals
• Asthma (immunology, physiopathology)
• Humans
• Hypersensitivity, Immediate (immunology, physiopathology)
• Inflammasomes
• Inflammation (immunology)
• Interleukin-1beta (immunology, metabolism)
• Mice
• Urticaria (immunology, physiopathology)