Abstract | BACKGROUND: OBJECTIVES: METHODS: RESULTS: Physiological and histological differences were not evident between ALD and control mice. AS mice developed AHR and allergic airway inflammation characterized by goblet cell hyperplasia and eosinophilic infiltration. Both AHR and airway eosinophilia were significantly enhanced in AS-ALD compared with AS mice. Serum total and Df-specific IgE were significantly increased in both AS and AS-ALD mice compared with control and ALD mice, but comparable between AS and AS-ALD mice. Mite allergen sensitization significantly increased interleukin-5 and granulocyte macrophage colony-stimulating factor, and decreased interferon-γ levels in the airways; injecting acetaldehyde into airways with allergic inflammation significantly increased the levels of these inflammatory cytokines. CONCLUSIONS:
|
Authors | Tetsuya Kawano, Hiroto Matsuse, Susumu Fukahori, Tomoko Tsuchida, Tomoya Nishino, Chizu Fukushima, Shigeru Kohno |
Journal | Respiration; international review of thoracic diseases
(Respiration)
Vol. 84
Issue 2
Pg. 135-41
( 2012)
ISSN: 1423-0356 [Electronic] Switzerland |
PMID | 22538484
(Publication Type: Journal Article)
|
Copyright | Copyright © 2012 S. Karger AG, Basel. |
Chemical References |
- Endocrine Disruptors
- Interleukin-5
- Volatile Organic Compounds
- Immunoglobulin E
- Interferon-gamma
- Granulocyte-Macrophage Colony-Stimulating Factor
- Acetaldehyde
|
Topics |
- Acetaldehyde
(pharmacology)
- Administration, Intranasal
- Animals
- Asthma
(immunology, pathology, physiopathology)
- Bronchoconstriction
(drug effects)
- Disease Models, Animal
- Endocrine Disruptors
(pharmacology)
- Eosinophilia
(chemically induced, metabolism)
- Female
- Granulocyte-Macrophage Colony-Stimulating Factor
(metabolism)
- Hypersensitivity
(immunology, pathology, physiopathology)
- Immunoglobulin E
(blood)
- Inflammation
(etiology, immunology, physiopathology)
- Interferon-gamma
(metabolism)
- Interleukin-5
(metabolism)
- Mice
- Mice, Inbred BALB C
- Respiratory System
(drug effects, immunology, pathology, physiopathology)
- Volatile Organic Compounds
(pharmacology)
|