Abstract | RATIONALE:
Vascular dementia and hypertension are increasing day by day, with a high degree of co-occurrence. Tremendous amount of research work is required so that new pharmacological agents may be identified for their appropriate therapeutic utility to combat different dementing disorders. OBJECTIVES: METHODS: RESULTS:
DOCA treatment significantly raised the mean arterial blood pressure of rats, and these hypertensive rats performed poorly on MWM, reflecting impairment of learning and memory. DOCA treatment also impaired vascular endothelial function and different biochemical parameters. Treatments of NDDCT as well as lisinopril significantly attenuated DOCA hypertension-induced impairment of learning and memory, endothelial dysfunction, and changes in various biochemical levels. CONCLUSIONS:
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Authors | Bhupesh Sharma, Nirmal Singh |
Journal | Psychopharmacology
(Psychopharmacology (Berl))
Vol. 223
Issue 3
Pg. 307-17
(Oct 2012)
ISSN: 1432-2072 [Electronic] Germany |
PMID | 22526544
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiotensin-Converting Enzyme Inhibitors
- NF-kappa B
- Desoxycorticosterone
- Ditiocarb
- Lisinopril
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Topics |
- Angiotensin-Converting Enzyme Inhibitors
(administration & dosage, therapeutic use)
- Animals
- Blood Pressure
(drug effects)
- Dementia, Vascular
(etiology, metabolism, prevention & control)
- Desoxycorticosterone
(analogs & derivatives, pharmacology)
- Disease Models, Animal
- Ditiocarb
(administration & dosage, therapeutic use)
- Endothelium, Vascular
(drug effects, physiopathology)
- Hypertension
(chemically induced, complications, drug therapy, metabolism)
- Lisinopril
(administration & dosage, therapeutic use)
- Male
- Maze Learning
(drug effects)
- Memory
(drug effects)
- NF-kappa B
(antagonists & inhibitors)
- Oxidative Stress
(drug effects)
- Rats
- Rats, Wistar
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