Superoxides (Superoxide)

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4406 relevant articles (110 outcomes, 406 trials/studies) found for this Bio-Agent

Description: Highly reactive compounds produced when oxygen is reduced by a single electron. In biological systems, they may be generated during the normal catalytic function of a number of enzymes and during the oxidation of hemoglobin to METHEMOGLOBIN. In living organisms, SUPEROXIDE DISMUTASE protects the cell from the deleterious effects of superoxides.

Also Known As:

Superoxide; Superoxide Anion; Superoxide Radical

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Salvemini, Daniela: 7 articles (12/2005 - 05/2002)
2.	Chen, Alex F: 6 articles (11/2006 - 02/2002)
3.	Fink, Gregory D: 5 articles (11/2003 - 02/2002)
4.	Li, Lixin: 5 articles (11/2003 - 02/2002)
5.	Andersen, Peter M: 4 articles (12/2006 - 01/2004)
6.	Jonsson, P Andreas: 4 articles (12/2006 - 01/2004)
7.	Brännström, Thomas: 4 articles (12/2006 - 01/2004)
8.	Marklund, Stefan L: 4 articles (12/2006 - 01/2004)
9.	Cuzzocrea, Salvatore: 4 articles (08/2004 - 01/2003)
10.	Galligan, James J: 4 articles (09/2003 - 02/2002)

Related Diseases

1.	Inflammation 02/01/1999 - "CONCLUSIONS: Superoxide anion may not play a major role in the genesis of inflammation in these rat inflammation models, and endotoxin-like contaminants may have contributed to some protective effects of SOD administration in previous studies." 02/01/2009 - "By using a cell-based test assay, the study investigated the potential of the functional drinks to inactivate reactive superoxide anion radicals generated by inflammation-mediating cells as well as the effect on basal metabolism of these cells (antioxidant and antiinflammatory potential). " 01/01/2007 - "Therefore, the aim of this study was to test the hypothesis that ET(A) receptor blockade attenuates superoxide production and inflammation in the kidney of diabetic rats. " 03/01/2001 - "To test this hypothesis, this study examined the effects of superoxide radical scavenging on pulpal inflammation induced in rat molars by standardized cavity preparation. " 03/01/1998 - "In this study, we modified the levels of endogenous NO. in vivo in an acute model of inflammation and evaluated the interactions between NO. and superoxide anion (O2-.) produced by polymorphonuclear leukocytes (PMNs) accumulated in the inflamed area. " Order ALL the reference details at left...
2.	Anoxia (Hypoxia) 05/01/2005 - "This study confirms that specific AOXs, known to act primarily as superoxide scavengers, protect contractile function in severe hypoxia. " 06/01/2004 - "This study demonstrated no effect of increased superoxide anion concentration on cerebral blood flow during hyperoxic recovery following hypoxia." 06/01/2003 - "The present study hypothesized that superoxide (O2(-)) importantly contributes to the regulation of hypoxia-inducible factor (HIF)-1alpha expression at posttranscriptional levels in renal medullary interstitial cells (RMICs) of rats. " 10/01/1999 - "The aim of the present study was to determine the role of endothelium and superoxide in the responses of isolated mouse coronary arteries to hypoxia-reoxygenation. " 10/01/2009 - "Nevertheless, the putative links between the mitodynamin responses, mitochondrial morphology and the changes in the mitochondrial bioenergetics, superoxide production, and hypoxia are yet to be elucidated, including the precise basis for signaling by the mitochondrion-derived vesicles." Order ALL the reference details at left...*
3.	Ischemia 12/01/2005 - "These results suggest that the effects of primary mechanical damage and secondary ischemia to cortical neurons are cumulative, and drugs that scavenge superoxide or reduce NO production may not be effective for treating the secondary ischemia that often accompanies TBI." 01/01/2002 - "The aim of this study was the online detection of superoxide concentration during reperfusion after a variable time of ischemia. " 09/01/1999 - "Using mice bearing a disruption of the CuZn-SOD gene (Sod1), the present study was designed to clarify the role of superoxide anion in the pathogenesis of selective vulnerability after transient global ischemia. " 04/01/1999 - "In the present study, it was found that the time course of superoxide production in ischemia-induced reperfused limbs showed a late polyphasic pattern without a significant initial peak, especially in the 6-hr ischemia group. " 04/14/1998 - "To determine whether increased SOD1 protects the heart from ischemia and reperfusion, studies were performed in a newly developed transgenic mouse model in which direct measurement of superoxide, contractile function, bioenergetics, and cell death could be performed. " Order ALL the reference details at left...
4.	Reperfusion Injury 12/01/1991 - "Results of this study suggest that superoxide radicals are involved in the pathogenesis of reperfusion injury in equine jejunal mucosa and that this may be of clinical importance in cases of small intestinal strangulation obstruction." 05/01/2009 - "Increased superoxide formation induced by irradiation preconditioning triggers kidney resistance to ischemia-reperfusion injury in mice." 11/01/2008 - "Thus, SOD mimetics protected mouse heart from superoxide-induced reperfusion injury. " 10/01/2006 - "The primary mechanism of cardioprotection appears to be antioxidant activity: potent direct scavenging of the lynchpin radical in ischemia-reperfusion injury, superoxide anion, has been documented in appropriate model systems. " 01/01/2006 - "Superoxide anion as a marker of ischemia-reperfusion injury of the transplanted kidney." Order ALL the reference details at left...
5.	Infection 07/20/1998 - "Taking into consideration that superoxide production in only 5 to 10% of wild-type neutrophils is sufficient to protect X-CGD heterozygotes from serious infections, the results achieved in this study shows that for X-CGD patients a curative approach based on the genetic modification of hematopoietic stem/progenitor cells is feasible." 11/01/1995 - "The pathophysiological roles of superoxide (O2.-) at the site of infection of facultative intracellular bacteria were examined in this study. " 01/01/2009 - "Superoxide production was detected histochemically in the vascular bundles and in the infected tissue of stem and root nodules, whereas peroxide accumulation was observed in the cortical cell walls and intercellular spaces, as well as within the infection threads of both nodule types. " 11/01/2008 - "HCV infection also caused oxidative stress via increased production of mitochondrial superoxide. " 01/01/2008 - "Neutrophils and monocytes are the first line of defence against bacterial and fungal infection through superoxide anion production during the respiratory burst. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Superoxide Dismutase
2.	Hydroxyl Radical
3.	Oxygen
4.	Reactive Oxygen Species (Oxygen Radicals)
5.	Peroxynitrous Acid (Peroxynitrite)
6.	Nitric Oxide (Nitrogen Monoxide)
7.	Hydrogen Peroxide (Hydroperoxide)
8.	NADPH Oxidase (NAD(P)H oxidase)
9.	Xanthine Oxidase
10.	Glutathione (Reduced Glutathione)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Aftercare (After-Treatment)
3.	Resuscitation
4.	Baths
5.	Intraperitoneal Injections

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