Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy)

970  relevant articles (73 outcomes, 211 trials/studies) found for this Disease

Subcortical Arteriosclerotic Encephalopathy; Dementia, Vascular; Acute Onset Vascular Dementia; Arteriosclerotic Encephalopathy, Subcortical; Binswanger Encephalopathy; Chronic Progressive Subcortical Encephalopathy; Encephalopathy, Binswanger's; Encephalopathy, Chronic Progressive Subcortical; Encephalopathy, Subcortical Arteriosclerotic; Encephalopathy, Subcortical, Chronic Progressive; Subcortical Encephalopathy, Chronic Progressive; Subcortical Leukoencephalopathy; Subcortical Vascular Dementia; Vascular Dementia, Acute Onset; Arteriosclerotic Dementias; Arteriosclerotic Encephalopathies, Subcortical; Binswanger's Encephalopathy; Dementia, Arteriosclerotic; Dementia, Subcortical Vascular; Dementias, Arteriosclerotic; Dementias, Subcortical Vascular; Dementias, Vascular; Disease, Binswanger; Encephalopathies, Subcortical Arteriosclerotic; Encephalopathy, Binswangers; Leukoencephalopathies, Subcortical; Subcortical Arteriosclerotic Encephalopathies; Subcortical Leukoencephalopathies; Subcortical Vascular Dementias; Vascular Dementia, Subcortical; Vascular Dementias; Vascular Dementias, Subcortical; Arteriosclerotic Dementia; Binswanger Disease; Encephalopathy, Binswanger; Leukoencephalopathy, Subcortical

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease)
2.	Dementia (Dementias)
3.	Multi-Infarct Dementia (Dementia, Multi Infarct)
4.	Parkinson Disease (Parkinson's Disease)
5.	Stroke (Strokes)

Experts

1.	Antonello, Rodolfo M: 8 articles (04/2008 - 11/2002)
2.	Moretti, Rita: 8 articles (04/2008 - 11/2002)
3.	Torre, Paola: 8 articles (04/2008 - 11/2002)
4.	Cazzato, Giuseppe: 8 articles (04/2008 - 11/2002)
5.	Huang, Yong: 5 articles (07/2007 - 09/2005)
6.	Erkinjuntti, Timo: 5 articles (11/2004 - 04/2002)
7.	Bava, Antonio: 5 articles (06/2004 - 11/2002)
8.	Spada, R S: 5 articles (01/2001 - 05/2000)
9.	Katagiri, Takashi: 4 articles (11/2007 - 04/2004)
10.	Iguchi, Takashi: 4 articles (11/2007 - 04/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Vascular Dementia:

1.	Memantine (Namenda)FDA Link 08/01/2004 - "Memantine treatment also has demonstrated significant improvement of cognitive performance in patients suffering from vascular dementia. " 10/01/2003 - "Memantine is beneficial in the treatment of severe and moderate-to-severe AD and may also be of some benefit in the treatment of mild-to-moderate vascular dementia. " 07/01/2002 - "CONCLUSIONS: In patients with mild to moderate vascular dementia, memantine 20 mg/d improved cognition consistently across different cognitive scales, with at least no deterioration in global functioning and behavior. " 11/01/2002 - "The aim of the reported trial was to investigate the safety and efficacy of memantine in mild to moderate vascular dementia (VaD). " 08/01/2003 - "The efficacy of memantine in vascular dementia also requires further investigation." Order ALL the reference details at left...
2.	Galantamine (Galanthamine)IBA 07/31/2007 - "Galantamine was effective for improving cognition, including executive function, in patients with vascular dementia, with good safety and tolerability. " 07/31/2007 - "Galantamine treatment of vascular dementia: a randomized trial." 01/01/2003 - "RESULTS: Patients with probable vascular dementia treated with galantamine for 6 or 12 months showed significant improvements in ADAS-cog/11 scores versus baseline, which were maintained at the end of the 12-month study. " 01/01/2002 - "Galantamine has been shown to delay the onset of BPSD in mild to moderate AD patients in one placebo-controlled study, and improve BPSD in a similar study of patients with cerebrovascular disease or probable vascular dementia. " 01/01/2009 - "[The use of reminil (galantamine) in the treatment of probable vascular dementia]" Order ALL the reference details at left...
3.	donepezil (Aricept)FDA LinkGeneric 08/01/2009 - "CONCLUSIONS: Donepezil-treated patients with Binswanger type subcortical vascular dementia demonstrated significant improvement in cognition compared with baseline, and donepezil was well tolerated." 03/01/2004 - "Donepezil minimally effective for patients with vascular dementia." 10/01/2003 - "Efficacy and tolerability of donepezil in vascular dementia: positive results of a 24-week, multicenter, international, randomized, placebo-controlled clinical trial." 10/01/2007 - "OBJECTIVE: To study the efficacy and safety of the combined treatment with compound Reinhartdt and Sea Cumber Capsule (RSC, a Chinese medicinal preparation consisted mainly of Reinhartdt and Sea Cumber) and Donepezil for vascular dementia (VD), and its effect on thyroid function axis. " 10/01/2007 - "[Clinical study of combined treatment with compound Reinhartdt and Sea Cumber Capsule and donepezil for vascular dementia]" Order ALL the reference details at left...
4.	rivastigmine (Exelon)FDA LinkGeneric 05/01/2005 - "Small open-label studies of patients with subcortical vascular dementia showed that rivastigmine improved attention, executive function, apathy and other behavioral deficits. " 09/01/2008 - "METHODS: VantagE (Vascular Dementia trial studying Exelon) was a 24-week, multicentre, double-blind study. " 09/01/2008 - "Efficacy, safety and tolerability of rivastigmine capsules in patients with probable vascular dementia: the VantagE study." 05/01/2005 - "Rivastigmine appears to be a promising agent in vascular dementia but its effects remain to be established in double-blind, placebo-controlled clinical trials." 09/01/2003 - "Rivastigmine in subcortical vascular dementia: a randomized, controlled, open 12-month study in 208 patients." Order ALL the reference details at left...
5.	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 11/01/1998 - "Most specialists (69%) believed that an RCT to assess the efficacy of aspirin in vascular dementia is warranted. " 01/01/2000 - "REVIEWER'S CONCLUSIONS: There is very limited evidence that aspirin is effective in treating patients with a diagnosis of vascular dementia. " 01/01/2000 - "REVIEWER'S CONCLUSIONS: There is no evidence that aspirin is effective in treating patients with a diagnosis of vascular dementia. " 01/01/2003 - "Aspirin in reducing events in the elderly (ASPREE) is a placebo-controlled trial of low-dose aspirin for the primary prevention of major adverse cardiovascular events and vascular dementia. " 01/01/2003 - "Rationale for a trial of low-dose aspirin for the primary prevention of major adverse cardiovascular events and vascular dementia in the elderly: Aspirin in Reducing Events in the Elderly (ASPREE)." Order ALL the reference details at left...
6.	propentofyllineIBA 10/01/1999 - "The neuroprotective glial cell modulator propentofylline has been used in clinical trials involving more than 800 patients with vascular dementia (VaD). " 10/01/1999 - "Clinical trials of propentofylline in vascular dementia. " 04/01/2008 - "Propentofylline is a novel xantine derivative which is being developed for treatment of degenerative and vascular dementia. " 04/01/2000 - "A Canadian economic evaluation of propentofylline (a therapy shown to be effective for patients with mild to moderate Alzheimer disease and/or vascular dementia) versus standard care was conducted. " 12/01/1998 - "Propentofylline (PPF, 3-methyl-1-(5-oxohexyl)-7-propylxanthine) has been reported to be effective for the treatment of both vascular dementia and dementia of the Alzheimer type. " Order ALL the reference details at left...
7.	choto-sanIBA 11/01/1999 - "These results suggest that Choto-san is effective in the treatment of vascular dementia. " 11/01/1999 - "Two different multicenter studies on the efficacy of Choto-san on patients with vascular dementia, one a well-controlled but non-double blind (60 patients), the other a double-blind controlled study (139 patients), were performed. " 06/01/2003 - "To clarify the clinical efficacy of one of the traditional medicines in the treatment of patients with vascular dementia, we investigated the pharmacological activities of Choto-san in animal models. " 09/01/2004 - "Previously, we revealed that Choto-san (Diao-teng-san in Chinese), a Kampo formula, is effective on vascular dementia clinically, and the hooks and stems of Uncaria sinensis (Oliv.) Havil., a medicinal plant comprising Chotosan, has a neuroprotective effect in vitro. " 07/01/2005 - "A recent double-blind and placebo-controlled study demonstrated a beneficial effect of Choto-san, a Kampo (traditional medicine of Japan) formula, on cognitive impairment in patients with vascular dementia. " Order ALL the reference details at left...
8.	Cholinesterase Inhibitors (Anticholinesterases)IBA 01/01/2002 - "Lately, this concept is tested by several studies on the efficacy of acetylcholinesterase inhibitors in vascular dementia." 05/01/2007 - "Evidence from randomised, placebo-controlled studies of cholinesterase inhibitors for vascular dementia suggests that there may be beneficial effects for cognitive function, and clinical global impression is more favourable for the cholinesterase inhibitors compared with placebo. " 11/15/2004 - "Treatment of vascular dementia--evidence from clinical trials with cholinesterase inhibitors." 07/01/2004 - "Treatment of vascular dementia-evidence from clinical trials with cholinesterase inhibitors." 06/15/2007 - "Cholinesterase inhibitors are also under investigation for treating cognitive dysfunction of cerebrovascular origin, but to date they do not have specific indication for vascular dementia or vascular cognitive impairment. " Order ALL the reference details at left...
9.	Nimodipine (Modus)FDA LinkGeneric 09/01/2009 - "OBJECTIVE: To study the therapeutic effects of acupuncture combined with nimodipine for vascular dementia. " 03/01/2005 - "Efficacy and safety of nimodipine in subcortical vascular dementia: a randomized placebo-controlled trial." 10/01/1999 - "Nimodipine in subcortical vascular dementia trial." 09/01/2009 - "CONCLUSION: Acupuncture at Baihui (GV 20), Shenshu (BL 23), Geshu (BL 17), and the points selected according to the midnight-noon, ebb-flow eight methods of the intelligent turtle combined with the drug nimodipine can yield definite therapeutic effects for vascular dementia." 09/01/2009 - "Clinical effects of acupuncture combined with nimodipine for treatment of vascular dementia in 30 cases." Order ALL the reference details at left...
10.	Glucose (Dextrose)FDA LinkGeneric 01/01/1998 - "A subsequent phase II study using positron emission tomography (PET) revealed that cortical glucose metabolism improved significantly in patients with vascular dementia after 12 weeks of PPF treatment but deteriorated significantly with placebo. " 05/01/2006 - "CONCLUSION: The effect of needling at Baihui(DU20), Shuigou(DU26) and Shenmen(HT7) on vascular dementia is closely related to improved cerebral glucose metabolism." 03/13/2009 - "Our recent studies have demonstrated that needling in Baihui, Shuigou and Shenmen enhances glucose metabolism in the frontal lobes, thalamus, temporal lobe, and the lentiform nucleus in vascular dementia. " 09/30/2008 - "Impaired glucose tolerance increased the risk of vascular dementia (hazard ratio for 1 SD decrease, 1.45; 95% CI, 1.05-2.00) but not AD. " 07/01/2007 - "Acupuncture increases cerebral glucose metabolism in human vascular dementia." Order ALL the reference details at left...

Therapies and Procedures

1.	Activities of Daily Living (ADL) 01/01/2006 - "Pooled data from three unpublished studies indicate a marginal beneficial effect at six months on ITT cognition (0.99 points on the 70 point ADAS-Cog, 95% CI 0.21 to 1.78, P = 0.01) which was barely detectable clinically (0.13 CIBIC+ points, 95% CI 0.01 to 0.25, P = 0.03) but no effect on behaviour, activities of daily living or OC analysis of cognition.3. Mild to moderate vascular dementia. " 01/01/2002 - "In the present study, we examined the relationships between ratings on the Global Deterioration Scale (GDS) and activities of daily living and cognitive function in 39 individuals with vascular dementia (VaD). " 10/01/1999 - "Outcome measures for the study of activities of daily living in vascular dementia." 10/01/2008 - "[Effect of long-time retention of scalp needle on the abilities of cognition, daily living activity and P300 in vascular dementia patients]" 01/01/2004 - "In this review, methods for assessing and tracking activities of daily living are discussed and the literature on the correlates of functional impairment in vascular dementia is summarized. " Order ALL the reference details at left...
2.	East Asian Traditional Medicine (Oriental Medicine) 04/01/2000 - "Hwansodan has been used as a prescription for senile and vascular dementia in Oriental medicine. " 12/01/2007 - "In this study, we investigated the effect of chotosan, an oriental medicine, which has been clinically demonstrated to be effective for the treatment of vascular dementia, on M-CSF gene expression in rats with permanent occlusion of bilateral common carotid arteries (P2VO) in vivo and in a C6Bu-1 glioma cell line in vitro. " Order ALL the reference details at left...
3.	Electroacupuncture 11/01/2008 - "[Clinically multi-central randomized controlled study on scalp electroacupuncture for treatment of vascular dementia]" 10/01/2008 - "OBJECTIVE: To study the underlying mechanism of electroacupuncture (EA) in improving learning-memory ability in vascular dementia (VD) rats. " 03/01/2009 - "OBJECTIVE: To investigate the clinical effects of electroacupuncture (EA) on the head points for improving gnosia in patients with vascular dementia (VD). " 03/01/2009 - "Electroacupuncture on the head points for improving gnosia in patients with vascular dementia." 12/01/2008 - "OBJECTIVE: To observe the effect of electroacupuncture (EA) on hippocampal apoptosis and learning-memory ability in vascular dementia (VD) mice so as to investigate its underlying mechanism in the treatment of VD patients. " Order ALL the reference details at left...
4.	Drug Therapy (Chemotherapy) 12/01/1993 - "[Prevention and pharmacotherapy of vascular dementia]" 11/01/2002 - "This conclusion is supported by the following evidence: (1) epidemiologic studies linking vascular risk factors to cerebrovascular pathology that can set in motion metabolic, neurodegenerative, and cognitive changes in Alzheimer brains; (2) evidence that AD and vascular dementia (VaD) share many similar risk factors; (3) evidence that pharmacotherapy that improves cerebrovascular insufficiency also improves AD symptoms; (4) evidence that preclinical detection of potential AD is possible from direct or indirect regional cerebral perfusion measurements; (5) evidence of overlapping clinical symptoms in AD and VaD; (6) evidence of parallel cerebrovascular and neurodegenerative pathology in AD and VaD; (7) evidence that cerebral hypoperfusion can trigger hypometabolic, cognitive, and degenerative changes; and (8) evidence that AD clinical symptoms arise from cerebromicrovascular pathology. " 09/01/1998 - "Aside the secondary prevention of stroke, no drug therapy influencing cognition or neuronal damage has been proved to be useful in patients with vascular dementia." 04/01/2002 - "This conclusion is based on the following evidence: (1) epidemiological studies showing that practically all risk factors for AD reported thus far have a vascular component that reduces cerebral perfusion; (2) risk factor association between AD and vascular dementia (VaD); (3) improvement of cerebral perfusion obtained from most pharmacotherapy used to reduce the symptoms or progression of AD; (4) detection of regional cerebral hypoperfusion with the use of neuroimaging techniques to preclinically identify AD candidates; (5) presence of regional brain microvascular abnormalities before cognitive and neurodegenerative changes; (6) common overlap of clinical AD and VaD cognitive symptoms; (7) similarity of cerebrovascular lesions present in most AD and VaD patients; (8) presence of cerebral hypoperfusion preceding hypometabolism, cognitive decline, and neurodegeneration in AD; and (9) confirmation of the heterogeneous and multifactorial nature of AD, likely resulting from the diverse presence of vascular risk factors or indicators of vascular disease. " 12/15/2004 - "MEDLINE was searched for English-language articles published within the last 10 years using the keywords mixed dementia, the combination of keywords Alzheimer disease, cerebrovascular disorders, and drug therapy, and the combination of keywords vascular dementia and drug therapy. " Order ALL the reference details at left...
5.	Acupuncture Points (Acupuncture Point) 09/01/2005 - "OBJECTIVE: To study the relative specialty of the acupoints of Baihui (DU20), Shuigou (DU26) and Shenmen (HT7) in treating vascular dementia (VD). " 06/01/2007 - "OBJECTIVE: Using methods of clinical scale assessment and cerebral functional imaging to compare the relative specificity of needling acupoints Baihui (DU20), Shuigou (DU26) and Shenmen (HT7) in intervening vascular dementia (VD) in different areas in the brain. " 06/01/2007 - "Comparative study of the specificities of needling acupoints DU20, DU26 and HT7 in intervening vascular dementia in different areas in the brain on the basis of scale assessment and cerebral functional imaging." 09/01/2005 - "[A comparative study on the acupoints of specialty of Baihui, Shuigou and Shenmen in treating vascular dementia.]" 05/01/2006 - "METHODS: Ten patients with vascular dementia were randomized into 2 groups, and the patients in the control group received the treatment with needling in the routine acupoints for hemiplegia (chosen from 6 Yang meridians of the hand and foot), while those in treatment group received needling at 3 additional acupoints, namely Baihui(DU20), Shuigou(DU26) and Shenmen(HT7), which were specific for dementia treatment. " Order ALL the reference details at left...