Relationship between serum interleukin-1beta levels and acute phase response proteins in patients with familial Mediterranean fever.

Abstract

INTRODUCTION:

The aim of this study was to investigate whether serum levels of interleukin-1beta (IL-1beta) has any possible correlation on inflammatory parameters such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and fibrinogen concentration in patients with familial Mediterranean fever (FMF) patients during attack-free period.

MATERIALS AND METHODS:

The serum levels of IL-1beta, as an indicator of cytokines status, and the acute phase response proteins, CRP, ESR and fibrinogen levels were evaluated in 35 attack-free patients with FMF and 25 healthy volunteers.

RESULTS:

Serum IL-1beta levels were significantly higher in patients with FMF than control subjects (P = 0.018). There was no statistically significant difference in the serum levels of ESR, CRP and fibrinogen between two groups (P = 0.181, P = 0.816, P = 0.686, respectively). There was a significant correlation between IL-1beta and CRP (r = 0.513, P = 0.002) values of FMF group.

CONCLUSIONS:

In conclusion, our results confirm the presence of increased IL-1beta levels in FMF patients during attack-free period. Serum IL-1beta values seems to correlate with CRP levels. The elevation of IL-1beta levels may be important in monitoring subclinical inflammation of attack free period in FMF patients.

• Authors: Kadir Yildirim, Hulya Uzkeser, Mustafa Keles, Saliha Karatay, Ahmet Kiziltunc, Muhammet Dursun Kaya, Abdulkadir Yildirim
• Journal: Biochemia medica (Biochem Med (Zagreb)) Vol. 22 Issue 1 Pg. 109-13 ( 2012) ISSN: 1330-0962 [Print] Croatia
• PMID: 22384525 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Acute-Phase Proteins
• Interleukin-1beta
• Fibrinogen
• C-Reactive Protein

Topics

• Acute-Phase Proteins (metabolism)
• Acute-Phase Reaction (blood)
• Adult
• Blood Sedimentation
• C-Reactive Protein (metabolism)
• Case-Control Studies
• Familial Mediterranean Fever (blood)
• Female
• Fibrinogen (metabolism)
• Humans
• Interleukin-1beta (blood)
• Male
• Middle Aged
• Young Adult