Familial Mediterranean Fever (Periodic Disease)

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613 relevant articles (38 outcomes, 47 trials/studies) found for this Disease

Description: An autosomal recessive inherited disease characterized by episodic FEVER; severe ABDOMINAL PAIN; PLEURISY; ARTHRITIS; and a characteristic ankle RASH. Disease flare-ups tend to last 3 days, and individuals are asymptomatic between attacks. ORCHITIS; benign recurrent MENINGITIS; HEADACHE; and AMYLOID nephropathy may also occur. (From Medicine (Baltimore) 1998 Jul;77(4):268-97)

Also Known As:

Periodic Disease; Mediterranean Fever, Familial; Wolff Periodic Disease; Periodic Disease, Wolff's; Periodic Fever Syndromes, Hereditary; Wolff's Periodic Disease; Fever, Familial Mediterranean; Hereditary Periodic Fever Syndromes

Relationship Network

Disease Context: Research Results

Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 422

Inborn Genetic Diseases: 549

Familial Mediterranean Fever: 613

Immune System Diseases: 1237

Autoimmune Diseases: 11588

Familial Mediterranean Fever: 613

Related Diseases

1.	Amyloidosis
2.	Pericarditis
3.	Fever (Fevers)
4.	Nephrotic Syndrome (Syndrome, Nephrotic)
5.	Infection

Experts

1.	Livneh, Avi: 11 articles (07/2008 - 04/2003)
2.	Kiraz, S: 6 articles (07/2007 - 08/2001)
3.	Livneh, A: 5 articles (07/2008 - 10/2000)
4.	Lidar, Merav: 5 articles (07/2008 - 12/2003)
5.	Kiraz, Sedat: 5 articles (07/2007 - 01/2005)
6.	Ertenli, I: 5 articles (07/2007 - 08/2001)
7.	Ozen, Seza: 5 articles (02/2007 - 05/2003)
8.	Kastner, Daniel L: 4 articles (09/2008 - 07/2003)
9.	Ureten, Kemal: 4 articles (05/2008 - 05/2005)
10.	Oztürk, Mehmet Akif: 4 articles (05/2008 - 01/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Familial Mediterranean Fever:

1.	Colchicine FDA Link 01/01/1983 - "Of 85 patients with familial Mediterranean fever receiving continuous prophylactic colchicine therapy, 62 (73 percent) have had a significant reduction in the severity and frequency of their attacks" 07/01/2007 - "OBJECTIVE: Colchicine is a mainstay of treatment in familial Mediterranean fever (FMF); however, 5%-10% of patients do not respond to colchicine" 01/01/1995 - "Recently, colchicine was shown to be effective in inflammatory diseases such as familial Mediterranean fever" 07/27/1996 - "Efficacy of colchicine in familial Mediterranean fever is well established." 04/15/1978 - "Prolonged remission with colchicine in a case of familial mediterranean fever]" Order ALL the reference details at left...
2.	Interferon-alpha (Interferon Alfa)FDA Link 07/01/2004 - "The effect of interferon alpha administration on acute attacks of familial Mediterranean fever: A double-blind, placebo-controlled trial." 11/01/1996 - "Resolving familial Mediterranean fever attacks with interferon alpha." 07/01/2004 - "The efficacy of interferon-alpha in a patient with resistant familial Mediterranean fever complicated by polyarteritis nodosa." 11/01/2004 - "Interferon alfa in protracted arthritis of familial Mediterranean fever: a robust alternative for synovectomy." 07/01/2004 - "The efficacy of continuous interferon alpha administration as an adjunctive agent to colchicine-resistant familial Mediterranean fever patients." Order ALL the reference details at left...
3.	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 06/05/2007 - "Treatment of familial Mediterranean fever with anakinra." 11/01/2007 - "Effective treatment of a colchicine-resistant familial Mediterranean fever patient with anakinra." 06/01/2008 - "The efficacy of anakinra in an adolescent with colchicine-resistant familial Mediterranean fever." 07/01/2008 - "Anakinra: new therapeutic approach in children with Familial Mediterranean Fever resistant to colchicine." 11/01/2007 - "Anakinra in two adolescent female patients suffering from colchicine-resistant familial Mediterranean fever: effective but risky." Order ALL the reference details at left...
4.	Amyloid (Amyloid Fibrils)IBA 11/01/1962 - "A study of the fine structure of the amyloid associated with familial Mediterranean fever." 11/01/2002 - "Amyloid goitre in familial Mediterranean fever: report on three patients and review of the literature." 01/01/2000 - "Amyloid nephropathy was the presenting symptom in a case of Familial Mediterranean Fever (FMF)" 02/01/1999 - "Familial Mediterranean fever--renal involvement by diseases other than amyloid." 11/15/1987 - "However, there are 10 nucleotide and 7 derived amino acid substitutions in exon 4. These changes are identical to the amino acid sequence of the amyloid protein associated with familial Mediterranean fever" Order ALL the reference details at left...
5.	Adrenocorticotropic Hormone (ACTH)FDA Link 08/01/1957 - "A case of periodic disease cured by ACTH." 07/01/2002 - "OBJECTIVE: To study cortisol, adrenocorticotropic hormone and C-reactive protein responses to specific stimuli in familial Mediterranean fever (FMF)" Order ALL the reference details at left...
6.	marenostrin (pyrin)IBA 09/01/2008 - "BACKGROUND: Familial Mediterranean fever (FMF) is an autosomal recessive disorder, caused by mutations in MEFV gene that encodes pyrin protein" 09/01/2008 - "Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by mutations in MEFV, which encodes a 781-amino acid protein denoted pyrin" 10/26/2007 - "Here, we demonstrate that PSTPIP1 requires the familial Mediterranean fever protein pyrin to assemble the ASC pyroptosome, a molecular platform that recruits and activates caspase-1" 08/01/2007 - "In patients with another autoinflammatory disorder, familial Mediterranean fever (FMF), mutations in the SPRY domain of the Pyrin protein are frequently found" 08/01/2007 - "The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing." Order ALL the reference details at left...
7.	infliximab (Remicade)FDA Link 02/01/2006 - "Familial Mediterranean fever responds well to infliximab: single case experience." 10/01/2006 - "Clinical improvement with infliximab in a child with amyloidosis secondary to familial Mediterranean fever." 02/15/2005 - "Infliximab therapy in a patient with familial Mediterranean fever and chronic hip arthritis." 01/01/2007 - "Successful treatment with infliximab and low-dose methotrexate in a Japanese patient with familial Mediterranean fever." 01/01/2007 - "We report a Japanese patient with familial Mediterranean fever (FMF) who was successfully treated with the anti-tumor necrosis factor (TNF)-alpha monoclonal antibody, infliximab, and low-dose methotrexate" Order ALL the reference details at left...
8.	Dimethyl Sulfoxide (DMSO)FDA LinkGeneric 12/01/1982 - "Continuous oral dimethylsulphoxide (DMSO) treatment (7-15 g/day) was given to 3 patients with amyloidosis of familial Mediterranean fever (FMF), 3 patients with idiopathic amyloidosis, and 7 patients with secondary amyloidosis" 01/01/1988 - "Colchicine is the drug of choice in the prevention and treatment of the renal amyloidosis associated with familial Mediterranean fever, and dimethylsulfoxide may be useful in the management of patients with secondary systemic amyloidosis" 01/01/1991 - "The results of treatment are still disappointing: alkylating agents and/or cortico-steroids are used in primary forms and for amyloidosis of myeloma; colchicine in familial Mediterranean fever; DMSO in renal amyloidosis; plasmapheresis in inherited-familial forms, together with the supportive management obviously dictated by clinical manifestations." Order ALL the reference details at left...
9.	P-GlycoproteinIBA 11/01/1998 - "Does the lack of the P-glycoprotein efflux pump in neutrophils explain the efficacy of colchicine in familial Mediterranean fever and other inflammatory diseases?" Order ALL the reference details at left...
10.	Lithium Carbonate (Eskalith)FDA LinkGeneric 09/01/1983 - "Efficacy of lithium carbonate in patients with periodic disease]" Order ALL the reference details at left...

Therapies and Procedures

1.	Transplantation (Transplant Recipients) 01/01/2008 - "In this report, we have described a renal transplant recipient with delayed gastric emptying secondary to amyloidosis due to familial Mediterranean fever, which improved with erithromycin treatment." 08/01/2003 - "Amyloidosis was secondary to familial Mediterranean fever (FMF) in 16 patients, whereas it was primary (idiopathic) in 7 transplant recipients" 01/01/2003 - "We report the case of a 26-year-old renal transplant recipient with familial Mediterranean fever who developed tuberculous ileitis" 01/01/2003 - "Tuberculous ileitis in a renal transplant recipient with familial Mediterranean fever: Gray-scale and power Doppler sonographic findings." 03/01/2001 - "Cardiac and intestinal amyloidosis in a renal transplant recipient with familial Mediterranean fever." Order ALL the reference details at left...
2.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 08/01/2002 - "Allogeneic bone marrow transplantation: cure for familial Mediterranean fever." 08/01/2007 - "Transmission of familial Mediterranean fever mutations following bone marrow transplantation." 07/01/2003 - "Allogenic bone marrow transplantation: not a treatment yet for familial Mediterranean fever." Order ALL the reference details at left...
3.	Thyroidectomy 12/01/1989 - "Subtotal thyroidectomy and oral colchicine administration, known to be effective in preventing complications of familial Mediterranean fever, another hereditary type of AA amyloidosis, proved highly effective in the management of this unusual case." Order ALL the reference details at left...
4.	Hip Replacement Arthroplasty (Total Hip Replacement) 01/01/1993 - "Total hip replacement in familial Mediterranean fever." 07/01/2005 - "INTRODUCTION: Recent studies have demonstrated that Colchicine (CO) prevents heterotopic ossification (HO) after total hip replacement in patients suffering from familial Mediterranean fever (FMF)" Order ALL the reference details at left...
5.	Fat-Restricted Diet (Diet, Fat Restricted) 08/01/1962 - "Low-fat diet in familial Mediterranean fever; a therapeutic trial." Order ALL the reference details at left...

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