[A case report of high plasma renin activity in chronic pulmonary disease and the effect of angiotensin-II-analogue (1-sarcosine, 8-isoleucine-angiotensin-II)].

Abstract

Five patients with chronic pulmonary diseases (3 pulmonary emphysema, 1 chronic respiratory failure caused by old tuberculosis, 1 diffuse panbronchiolitis) showed a marked increase of plasma angiotensin-I and PRA level, which was accompanied by an increase of angiotensin-II level, however, whose systemic blood pressure was not elevated. The intravenous infusion of angiotensin-II-analogue (1-Sarcosine, 8-Isoleucine-Angiotensin-II) elicited an antagonistic blood pressure response resembling Bartter's syndrome.

• Authors: T Nakano, T Yamamoto, H Fujioka, J Maeda, N Iwahashi, S Tamura, T Hada, K Higashino
• Journal: Nihon Kyobu Shikkan Gakkai zasshi (Nihon Kyobu Shikkan Gakkai Zasshi) Vol. 28 Issue 4 Pg. 605-11 (Apr 1990) ISSN: 0301-1542 [Print] Japan
• PMID: 2214403 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Angiotensin II
• Angiotensin I
• 1-Sarcosine-8-Isoleucine Angiotensin II
• Renin

Topics

• 1-Sarcosine-8-Isoleucine Angiotensin II (pharmacology)
• Angiotensin I (blood)
• Angiotensin II (blood)
• Blood Pressure (drug effects)
• Chronic Disease
• Female
• Humans
• Lung Diseases (blood, physiopathology)
• Male
• Renin (blood)