The expression level of lysophosphatidylcholine acyltransferase 1 (LPCAT1) correlates to the progression of prostate cancer.

Abstract

BACKGROUND:

Lysophosphatidylcholine acyltransferase 1 (LPCAT1), the enzyme catalyzing the reaction in remodeling of phosphatidylcholine (PC) has been reported to express in prostate. However, its diagnostic and prognostic values remain unclear.

METHODS:

Immunohistochemistry (IHC) for LPCAT1 was performed on the tissue microarray (TMA) slides containing 251 samples from 148 patients with various prostatic disorders. The association of expression level of LPCAT1 with the progression of prostate cancer was analyzed.

RESULTS:

LPCAT1 IHC mean score was the highest in metastatic prostate cancer (8.00±1.28), which was significantly higher than that in primary prostate cancer (4.63±3.00, p=9.73E-07), in high grade prostatic intraepithelial neoplasia (HGPIN, 2.72±2.47, p=1.02E-12), and in benign prostate (2.68, p=6.17E-12). The mean score in primary prostate cancer was significantly higher than that in HGPIN (p=4.09E-04) and in benign prostate (p=2.74E-04). There was no significant difference in the mean score between HGPIN and benign prostate (p=0.951). LPCAT1 IHC score also correlated to the tumor grade and stage of prostate cancer. Patients who underwent prostatectomy for prostate cancer and developed biochemical recurrence or clinical metastasis had higher LPCAT1 IHC score than those who underwent prostatectomy for prostate cancer and did not develop biochemical recurrence and clinical metastasis. The association of LPCAT1 with the progression of prostate cancer was independent of patient race and age, PSA level and positivity of surgical resection margins.

CONCLUSIONS:

LPCAT1 correlates with the progression of prostate cancer and could be a new biomarker in diagnosis, prognosis and studying the pathogenesis of prostate cancer.

• Authors: Xinchun Zhou, Thomas J Lawrence, Zhi He, Charles R Pound, Jinghe Mao, Steven A Bigler
• Journal: Experimental and molecular pathology (Exp Mol Pathol) Vol. 92 Issue 1 Pg. 105-10 (Feb 2012) ISSN: 1096-0945 [Electronic] Netherlands
• PMID: 22101258 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Published by Elsevier Inc.

Chemical References

• Biomarkers
• 1-Acylglycerophosphocholine O-Acyltransferase
• Prostate-Specific Antigen

Topics

• 1-Acylglycerophosphocholine O-Acyltransferase (metabolism)
• Aged
• Biomarkers
• Disease Progression
• Humans
• Immunohistochemistry
• Male
• Middle Aged
• Neoplasm Staging
• Paraffin Embedding
• Prognosis
• Prostate (enzymology, pathology, surgery)
• Prostate-Specific Antigen (metabolism)
• Prostatectomy
• Prostatic Intraepithelial Neoplasia (metabolism, pathology, secondary, surgery)
• Prostatic Neoplasms (metabolism, pathology, surgery)