Abstract | BACKGROUND: STUDY DESIGN: SETTING & PARTICIPANTS: 3,228 adult patients with type 2 diabetic nephropathy from IDNT and RENAAL were combined to establish the DIAMETRIC database. This is the largest global source of clinical information for patients with type 2 diabetic nephropathy who have decreased kidney function and significant proteinuria. INTERVENTION: OUTCOMES & MEASUREMENTS: Incidence rates of ESRD, cardiovascular death, and all-cause mortality. RESULTS: Mean follow-up was 2.8 years; 19.5% of patients developed ESRD, approximately 2.5 times the incidence of cardiovascular death and 1.5 times the incidence of all-cause mortality. ESRD was more common than cardiovascular death in all subgroups analyzed with the exception of participants with low levels of albuminuria ( albumin excretion <1.0 g/g) and well-preserved levels of kidney function (estimated glomerular filtration rate >45 mL/min/1.73 m(2)) at baseline. LIMITATIONS: All participants were included in a prospective clinical trial. CONCLUSIONS:
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Authors | David K Packham, Tahira P Alves, Jamie P Dwyer, Robert Atkins, Dick de Zeeuw, Mark Cooper, Shahnaz Shahinfar, Julia B Lewis, Hiddo J Lambers Heerspink |
Journal | American journal of kidney diseases : the official journal of the National Kidney Foundation
(Am J Kidney Dis)
Vol. 59
Issue 1
Pg. 75-83
(Jan 2012)
ISSN: 1523-6838 [Electronic] United States |
PMID | 22051245
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved. |
Topics |
- Cardiovascular Diseases
(etiology, mortality)
- Databases, Factual
- Diabetes Mellitus, Type 2
(complications)
- Diabetic Nephropathies
(complications)
- Female
- Humans
- Incidence
- Kidney Failure, Chronic
(epidemiology, etiology)
- Male
- Middle Aged
- Proteinuria
(complications)
- Retrospective Studies
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