Abstract | OBJECTIVE: Acidic mammalian chitinase (AMCase) has been found to play an important role in allergy and asthma. Chronic rhinosinusitis with nasal polyps (CRSwNPs) is chronic inflammation with eosinophilic infiltration, which is similar to asthmatic inflammation. The role of AMCase in CRSwNPs has been less studied. Eotaxin-3 is a potent eosinophil attractant and can induce eosinophil recruitment and activation in the airways of asthmatics. The expression and role of eotaxin-3 messenger ribonucleic acid ( mRNA) and its relationship to AMCase in CRSwNPs have not been studied previously. SUBJECTS AND METHODS: Twenty-three subjects with nasal polyps and nine subjects with nasal septum deviation were included in the study. The polyps and inferior turbinate mucosa were obtained as the tissue samples. Real-time reverse transcriptase-polymerase chain reaction was used to analyze and compare the expression levels of AMCase and eotaxin-3 in nasal polyps and inferior turbinate tissues (ITTs). RESULTS: CONCLUSIONS: Our results reveal that AMCase and eotaxin-3 may be important mediators in the pathogenesis of nasal polyps. The increased AMCase and eotaxin-3 might lead to nasal polyp formation and growth. Future studies are needed to determine the potential of AMCase and eotaxin-3 as therapeutic targets in CRSwNPs.
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Authors | ZhaoWei Gu, ZhiWei Cao, MingZhu Jin |
Journal | Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
(J Otolaryngol Head Neck Surg)
Vol. 40
Issue 1
Pg. 64-9
(Feb 2011)
ISSN: 1916-0216 [Electronic] England |
PMID | 21303604
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- CCL26 protein, human
- Chemokine CCL26
- Chemokines, CC
- RNA
- CHIA protein, human
- Chitinases
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Topics |
- Chemokine CCL26
- Chemokines, CC
(biosynthesis, genetics)
- Chitinases
(biosynthesis, genetics)
- Follow-Up Studies
- Gene Expression Regulation
- Genetic Predisposition to Disease
- Humans
- Nasal Polyps
(complications, genetics, metabolism)
- Polymerase Chain Reaction
- RNA
(genetics)
- Rhinitis
(complications, genetics, metabolism)
- Sinusitis
(complications, genetics, metabolism)
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