Chitinases

Glycoside hydrolases that break down glycosidic bonds in CHITIN. They are important for insect and worm morphogenesis and plant defense against pathogens. Human chitinases may play a role in the etiology of allergies and asthma.

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Networked: 1051 relevant articles (27 outcomes, 97 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Elias, Jack A: 47 articles (02/2022 - 06/2004)
2.	Lee, Chun Geun: 36 articles (02/2022 - 09/2005)
3.	Ma, Bing: 14 articles (02/2022 - 01/2011)
4.	Zhou, Yang: 13 articles (02/2022 - 06/2011)
5.	Lee, Chang-Min: 13 articles (01/2022 - 09/2012)
6.	Mizoguchi, Emiko: 13 articles (11/2021 - 02/2006)
7.	Chupp, Geoffrey L: 11 articles (10/2017 - 11/2007)
8.	Comabella, Manuel: 10 articles (11/2021 - 04/2010)
9.	Montalban, Xavier: 10 articles (11/2021 - 04/2010)
10.	Dela Cruz, Charles S: 9 articles (06/2020 - 01/2011)

Related Diseases

1.	Infections 06/01/2014 - "pseudoalcaligenes better helped the plant to overcome or suppress fungal pathogen infection by producing β-1, 3-glucanase and chitinase as well as also have enhanced dry weight, plant height, and root length. " 01/01/1999 - "Immunization of jirds with recombinant chitinase induced partial protection against microfilaremia resulting from subsequent infection with B. " 04/01/1997 - "Immunization of jirds with recombinant chitinase induced partial protection against microfilaremia resulting from subsequent infection with Brugia malayi, but did not reduce adult worm burdens. " 01/01/2022 - "In this study, genome-wide identification of the chitinase gene family of wild apple (Malus sieversii) and domesticated apple (Malus domestica) was conducted, and the expression profile was analyzed in response to Valsa mali infection. " 01/01/2019 - "Prior studies have shown that the production of chitinase by macrophages in the brain responding to TOXO infection is crucial for controlling the burden of T. "
2.	Asthma (Bronchial Asthma) 03/01/2014 - "In children with high preoperative circulating chitinase activity levels, asthma control and healthcare utilization were significantly improved after adenotonsillecotmy. " 03/01/2014 - "Higher chitinase activity levels at baseline were associated with improved asthma control following surgery (P < 0.01). " 01/01/2018 - "Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma." 04/01/2012 - "The inhibitors of chitinases not only have chemotherapeutic potential against fungi, insects, but also hold anti-inflammatory efficacy against asthma and allergic disease in human. " 06/01/2021 - "This study was aimed to investigate the associations among Chitinase 3-like 1 (CHI3L1) polymorphisms, asthma and plasma YKL-40 levels in Chinese population. "
3.	Inflammation (Inflammations) 01/01/2021 - "This study sought to evaluate the regulatory function of nuclear factor erythroid 2-related factor 2 (Nrf2) in a murine model of anterior cruciate ligament transection (ACLT)-induced PTOA and in an in vitro model of synoviocyte inflammation induced by LPS treatment with the goal of exploring the role of chitinase 3-like-1 (CHI3L1) in this pathogenic context. " 11/23/2022 - "Chitinase-like 3 protein-1 (CHI3L1) is expressed by activated neutrophils and may be a clinically informative marker of systemic inflammation in CLWH. " 01/01/2022 - "Activated Neutrophils Secrete Chitinase-Like 1 and Attenuate Liver Inflammation by Inhibiting Pro-Inflammatory Macrophage Responses." 01/01/2022 - "Chitinase 3-like 1 (Chi3L1) is associated with various biological processes, such as inflammation, tissue repair, proliferation, cell survival, invasion, and extracellular matrix remodeling. " 01/01/2021 - "Chitinase 3-like-1 protects airway function despite promoting type 2 inflammation during fungal-associated allergic airway inflammation."
4.	Mycoses (Diseases, Fungus) 12/01/2014 - "These results demonstrate potentiality of chitinase and RIP from a heterologous source in developing fungal disease protection in blackgram and can be helpful in increasing the production of blackgram." 01/01/2022 - "These results improve knowledge of the chitinase gene family in apple species and provide a foundation for further studies of fungal disease prevention in apple." 12/01/2023 - "Chitinase is regarded as capable of improving plant resistance to fungal diseases. " 01/01/2023 - "Mammalian chitinases and CLPs are produced by neutrophils, monocytes, and macrophages in response to parasitic or fungal infections. " 01/01/2023 - "Petioles of the overexpressing lines inoculated with Colletotrichum fioriniae had lower disease incidence than the WT, and leaves of these lines challenged by Botrytis cinerea showed significantly smaller lesion diameters than the WT and higher expression of CLASS II CHITINASE 2-1. Our results indicate that FaMBL1 plays important roles in strawberry response to fungal diseases caused by C. "
5.	Disease Resistance 08/15/2014 - "Our results indicated that the antagonistic yeast XL-1 significantly improved the activity of β-1,3-glucanase and chitinase to promote the disease resistance of postharvest cantaloupe." 12/01/2023 - "These findings indicate that chitinase PbChia1 is a candidate gene that can confer broad-spectrum disease resistance in breeding." 12/01/2023 - "Overexpression of chitinase PbChia1 from Plasmodiophora brassicae improves broad-spectrum disease resistance of Arabidopsis." 12/08/2022 - "These results suggest that the higher expression of β-1,3-glucanase, TLP, and chitinase after hydropriming and osmotic priming may increase disease resistance in wheat. " 01/01/2022 - "sativus groups with high disease resistance had abundant pathogen resistance genes, such as chitinase and β-1,3-glucanase genes, from rhizosphere microorganisms. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Chitinases
3.	Biomarkers (Surrogate Marker)
4.	Messenger RNA (mRNA)
5.	Methacholine Chloride (Methacholine)
6.	Enzymes
7.	Peptide Hydrolases (Proteases)
8.	Caffeine (No Doz)
9.	Antioxidants
10.	Defensins

Related Therapies and Procedures

1.	Therapeutics
2.	Kidney Transplantation
3.	Drug Therapy (Chemotherapy)
4.	Immunomodulation
5.	Aftercare (After-Treatment)