Abstract |
The presence of multiple myeloma (MM) in a patient with systemic sclerosis is a rare and unusual occurrence with unclear significance. We report the case of a 55-year-old woman with a 20-year history of systemic sclerosis, who subsequently presented with clinical stage IIIA IgG-λ MM. The systemic sclerosis was diagnosed and treated in 1988 with D: -penicillamine and methotrexate. Twenty years later, in December 2008, she presented with symptoms of Raynaud's phenomenon and intense facial pruritus. Immunoelectrophoresis confirmed the presence of a IgG-λ paraprotein (71.90 g/l) and Bence Jones proteinuria of the lambda light chains. Bone marrow histology revealed infiltrates of plasmocytes and lymphoplasmocytes which were on immunohistochemistry CD38+, FGF-R3+ and OPG+. An extensive X-ray skeletal survey did not show any osteolytic lesions or fractures. The patient was treated according to the CTD protocol ( cyclophosphamide, thalidomide, and dexamethasone) which was effective against the myeloma as well as the systemic sclerosis and patient achieved complete remission.
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Authors | Milica Čolović, Vladimir Jurisic, Jelena Bila, Natasa Čolović, Vuk Palibrk |
Journal | International journal of hematology
(Int J Hematol)
Vol. 93
Issue 2
Pg. 228-231
(Feb 2011)
ISSN: 1865-3774 [Electronic] Japan |
PMID | 21207214
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Osteoprotegerin
- TNFRSF11B protein, human
- FGFR3 protein, human
- Receptor, Fibroblast Growth Factor, Type 3
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Topics |
- Bone Marrow
(metabolism, pathology)
- Female
- Humans
- Middle Aged
- Multiple Myeloma
(complications, metabolism, pathology)
- Osteoprotegerin
(metabolism)
- Receptor, Fibroblast Growth Factor, Type 3
(metabolism)
- Scleroderma, Systemic
(complications)
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