The CRP 1846T/T genotype is associated with a poor prognosis in patients with non-small cell lung cancer.

Abstract

C-reactive protein (CRP) is one of the acute-phase proteins produced predominantly by hepatocytes in response to inflammation, and it has been widely reported that CRP genetic polymorphism is a risk factor for cardiovascular disease and ischemic stroke. In addition, we previously showed that the CRP 1846T/T genotype is related to lymph node metastasis in patients with esophageal cancer. In the present study, we investigated the correlation between CRP 1846C>T polymorphism and the clinicopathological characteristics of non-small cell lung cancer (NSCLC). The study participants were 146 Japanese patients who underwent curative surgery for NSCLC. DNA was extracted from tumor samples, and CRP1846C>T polymorphism was investigated using the polymerase chain reaction-restriction fragment length polymorphism method. We then correlated genotype with known clinicopathological factors. Five-year overall survival among patients with the CRP 1846T/T genotype was significantly lower than among those with the 1846C/C or C/T genotype (p = 0.002, p = 0.001; log-rank test). Multivariate Cox proportional hazard analysis revealed age, sex, pathological stage III, and 1846T/T (hazard ratio, 1.76; 95% confidence interval, 1.003-3.16; p = 0.049) to be independent factors affecting 5-year overall survival. These findings suggest the CRP 1846T/T genotype is an independent predictor of a poor prognosis in patients with NSCLC.

• Authors: Yoshihiro Minamiya, Masatomo Miura, Yudai Hinai, Hajime Saito, Manabu Ito, Kazuhiro Imai, Takashi Ono, Satoru Motoyama, Jun-ichi Ogawa
• Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol) Vol. 31 Issue 6 Pg. 673-9 (Dec 2010) ISSN: 1423-0380 [Electronic] Netherlands
• PMID: 20686879 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• C-Reactive Protein

Topics

• Aged
• C-Reactive Protein (genetics)
• Carcinoma, Non-Small-Cell Lung (diagnosis, genetics, mortality)
• Female
• Genotype
• Humans
• Japan
• Lung Neoplasms (diagnosis, genetics, mortality)
• Male
• Middle Aged
• Polymorphism, Genetic (genetics)
• Prognosis
• Proportional Hazards Models
• Survival Rate