Association between the neutrophil myeloperoxidase index and subsets of bacterial infections.

Abstract

The mean myeloperoxidase index (MPXI) is calculated during the routine complete blood count performed using the autoanalyzer ADVIA120/2120. The pattern of changes in the neutrophil myeloperoxidase levels in patients with specific infectious diseases was analyzed by assessing the MPXI levels. In patients with bacterial sepsis, identified by positive blood-culture tests, with (n = 29) and without (n = 51) systemic inflammatory response syndrome, the mean MPXI significantly reduced to -3.18 and -2.06, respectively. In contrast, among patients with nontuberculous nonseptic bacterial infections (n = 40), the mean MPXI significantly elevated to 5.51, while tuberculosis patients (n = 37) and patients with viral infection (n = 60) showed an unchanged MPXI (mean values, -0.46 and -1.06, respectively). Among the parameters of inflammation, only the C-reactive protein values showed a weak correlation with the MPXI levels. [Conclusion] These results indicate that MPXI is correlated with some specific infectious states, i.e. MPXI is low in bacterial sepsis and high in nontuberculous nonseptic bacterial infections. MPXI appears to be an independent and useful biomarker for the diagnosis and follow-up of infectious diseases, especially when the MPXI values are obtained at regular intervals during the disease courses of the patients.

• Authors: K Yonezawa, O Horie, A Yoshioka, S Matsuki, T Tenjin, Y Tsukamura, M Yoneda, K Shibata, Y Koike, T Nomura, M Yokoyama, N Urahama, Mitsuhiro Ito
• Journal: International journal of laboratory hematology (Int J Lab Hematol) Vol. 32 Issue 6 Pt 2 Pg. 598-605 (Dec 2010) ISSN: 1751-553X [Electronic] England
• PMID: 20201994 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2010 Blackwell Publishing Ltd.

Chemical References

• Biomarkers
• C-Reactive Protein
• Peroxidase

Topics

• Adolescent
• Adult
• Bacterial Infections (blood, enzymology)
• Biomarkers (blood)
• C-Reactive Protein (analysis)
• Child
• Child, Preschool
• Female
• Humans
• Infant
• Infant, Newborn
• Inflammation (enzymology)
• Male
• Middle Aged
• Neutrophils (enzymology)
• Peroxidase (blood)
• Sepsis (blood, enzymology)
• Tuberculosis (blood, enzymology)