Effect of tocopheryl phosphate on key biomarkers of inflammation: Implication in the reduction of atherosclerosis progression in a hypercholesterolaemic rabbit model.

Abstract

1. Many studies have evaluated the effectiveness of alpha-tocopherol (vitamin E) in the development and progression of cardiovascular diseases, with conflicting results reported on the protective effect of this anti-oxidant. 2. The present study examined the effectiveness of a novel tocopheryl phosphate mixture (TPm) compared with that of alpha-tocopherol (TA) on key pro-inflammatory markers involved in atherogenesis, including interleukin (IL)-1beta, IL-6, IL-8, plasminogen activator inhibitor-1, tumour necrosis factor-alpha and C-reactive protein (CRP), as well as vascular function and lesion development in rabbits fed a 2% cholesterol diet. 3. Treatment with TPm, incorporated into the rabbit food at four doses ranging from 60 to 360 mg/kg chow, resulted in a significant reduction in plasma levels of all pro-inflammatory cytokines and biomarkers that appeared to be somewhat dose dependent. Conversely, treatment with TA, at a dose equivalent to the highest dose of TPm used, only decreased plasma levels of CRP, IL-6 and IL-8. Both TPm and TA treatment significantly improved vascular function to a similar extent, although TPm was more effective in reducing lesion development. 4. The reduction in these key pro-inflammatory markers appears to follow the improvement in the atherogenic state of the animals, indicating that the anti-inflammatory properties of TPm may be potentially beneficial in inflammatory disease states.

• Authors: Roksan Libinaki, Sonja Tesanovic, Aileen Heal, Billie Nikolovski, Antony Vinh, Robert E Widdop, Tracey A Gaspari, Sridevi Devaraj, Esra Ogru
• Journal: Clinical and experimental pharmacology & physiology (Clin Exp Pharmacol Physiol) Vol. 37 Issue 5-6 Pg. 587-92 (May 2010) ISSN: 1440-1681 [Electronic] Australia
• PMID: 20082629 (Publication Type: Journal Article)

Chemical References

• Antioxidants
• Biomarkers
• Cytokines
• Lipids
• alpha-tocopherol phosphate
• alpha-Tocopherol

Topics

• Animals
• Antioxidants (administration & dosage, therapeutic use)
• Aorta (drug effects, pathology, physiopathology)
• Atherosclerosis (blood, etiology, immunology, pathology, prevention & control)
• Biomarkers (blood)
• Cytokines (blood, immunology)
• Diet, Atherogenic
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Hypercholesterolemia (blood, complications, immunology, pathology)
• In Vitro Techniques
• Lipids (blood)
• Male
• Rabbits
• Treatment Outcome
• Vasodilation (drug effects)
• alpha-Tocopherol (administration & dosage, analogs & derivatives, therapeutic use)