Abstract | PURPOSE: METHODS: Aqueous and vitreous samples were obtained during cataract surgery and vitreous surgery from 17 patients (17 eyes) with CRVO and macular edema. The levels of VEGF and IL-6 in aqueous humor, vitreous fluid, and plasma were determined by enzyme-linked immunosorbent assay. RESULTS: The aqueous levels of VEGF and IL-6 were significantly correlated with the vitreous levels of these molecules (rho=0.8799, p=0.0004 and rho=0.8088, p=0.0012, respectively). Vitreous levels of VEGF and IL-6 were significantly higher in CRVO patients with retinal ischemia than in those without ischemia (p=0.0013 and p=0.0009, respectively), as were the aqueous levels of VEGF and IL-6 (p=0.0026, p=0.0120, respectively). Furthermore, both the aqueous and vitreous levels of VEGF and IL-6 were significantly correlated with the severity of macular edema (rho=0.7181, p=0.0041; rho=0.8260, p=0.0010; rho=0.5564, p=0.0260; and rho=0.6599, p=0.0039, respectively). CONCLUSIONS: Our results suggest that aqueous levels of VEGF and IL-6 may reflect the vitreous levels of these molecules. Measurement of VEGF and IL-6 in the aqueous humor may be clinically useful to assess the severity of macular edema in patients with CRVO.
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Authors | Hidetaka Noma, Hideharu Funatsu, Tatsuya Mimura, Seiyo Harino, Sadao Hori |
Journal | European journal of ophthalmology
(Eur J Ophthalmol)
2010 Mar-Apr
Vol. 20
Issue 2
Pg. 402-9
ISSN: 1120-6721 [Print] United States |
PMID | 19967679
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Interleukin-6
- Vascular Endothelial Growth Factor A
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Topics |
- Aged
- Aged, 80 and over
- Aqueous Humor
(metabolism)
- Enzyme-Linked Immunosorbent Assay
- Female
- Fluorescein Angiography
- Follow-Up Studies
- Fundus Oculi
- Humans
- Interleukin-6
(metabolism)
- Macular Edema
(diagnosis, etiology, metabolism)
- Male
- Middle Aged
- Prognosis
- Retinal Vein Occlusion
(complications, diagnosis, metabolism)
- Retrospective Studies
- Severity of Illness Index
- Vascular Endothelial Growth Factor A
(metabolism)
- Vitreous Body
(metabolism)
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