Abstract | AIM: MATERIALS AND METHODS: The study was performed using genomic DNA samples from 574 Type 2 diabetic patients and 323 healthy controls. The SUMO4 Met55Val polymorphism was genotyped using allele-specific real-time PCR. RESULTS: The frequency of the G allele (encoding Val55) was significantly higher in Type 2 diabetic patients and Type 2 diabetic patients with the GG genotype had higher hemoglobin A1c level. Multivariate logistic regression analysis revealed the genotype of GG and GA was an independent risk factor contributing to the development of T2DM. CONCLUSION: This study suggests that in Taiwan the SUMO4 Met 55Val polymorphism is associated with susceptibility to T2DM and Type 2 diabetic patients with GG genotype have worse glycemic control.
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Authors | H Y Lin, S L Li, M L Yu, P J Hsiao, M C Hsieh, K D Lin, C L Wang, T N Wang, S J Shin |
Journal | Journal of endocrinological investigation
(J Endocrinol Invest)
Vol. 33
Issue 6
Pg. 401-5
(Jun 2010)
ISSN: 1720-8386 [Electronic] Italy |
PMID | 19915388
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- NF-kappa B
- SUMO4 protein, human
- Small Ubiquitin-Related Modifier Proteins
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Topics |
- Adult
- Aged
- Blood Glucose
(metabolism)
- Diabetes Mellitus, Type 2
(blood, genetics)
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Male
- Middle Aged
- NF-kappa B
(genetics)
- Polymorphism, Single Nucleotide
- Small Ubiquitin-Related Modifier Proteins
(genetics)
- Taiwan
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