Oxidized LDL and the metabolic syndrome.

Abstract

The metabolic syndrome is a common and complex disorder combining obesity, dyslipidemia, hypertension and insulin resistance. It is associated with a high cardiovascular risk that can only partially be explained by its components. There is evidence that low-grade inflammation and high oxidative stress add to this risk. Oxidized LDL, a marker of lipoprotein-associated oxidative stress, is an emerging cardiovascular risk factor. In this review, we demonstrate that the metabolic syndrome exacerbates oxidized LDL in a feedback loop. We introduce molecular mechanisms underlying this loop. Finally, we demonstrate that weight loss and statin treatment lower metabolic syndrome factors associated with a reduction of oxidized LDL. The current data warrant further investigation into the role of lifestyle and therapeutic interventions that inhibit tissue-associated oxidation of LDL in the prevention of the metabolic syndrome.

• Authors: Paul Holvoet, Dieuwke De Keyzer, David R Jacobs Jr
• Journal: Future lipidology (Future Lipidol) Vol. 3 Issue 6 Pg. 637-649 (Dec 2008) ISSN: 1746-0875 [Print] England
• PMID: 19802339 (Publication Type: Journal Article)