Abstract | OBJECTIVES: To determine the rates, reasons and predictors of treatment change of the initial antiretroviral treatment (ART) regimen in HIV-infected south Indian adults. METHODS: In this prospective cohort study, ART-naive adults initiated on generic, fixed dose combination ART as per the National AIDS Control Organization guidelines were followed up at an academic medical center. Treatment change was defined as any event which necessitated a change in or discontinuation of the initial ART regimen. RESULTS: CONCLUSIONS: The ART regimens used in this study were effective in decreasing disease progression and death. However, they were associated with high rates of drug toxicities, particularly those attributable to thymidine analogue NRTI. As efforts are made to improve access to ART, treatment regimens chosen should not only be potent, but also safe.
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Authors | Ajith Sivadasan, O C Abraham, Priscilla Rupali, Susanne A Pulimood, Joyce Rajan, S Rajkumar, Anand Zachariah, Rajesh Kannangai, Abraham Joseph Kandathil, G Sridharan, Dilip Mathai |
Journal | The Journal of the Association of Physicians of India
(J Assoc Physicians India)
Vol. 57
Pg. 384-8
(May 2009)
ISSN: 0004-5772 [Print] India |
PMID | 19634284
(Publication Type: Journal Article)
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Chemical References |
- Anti-HIV Agents
- Anti-Retroviral Agents
- Drugs, Generic
- Reverse Transcriptase Inhibitors
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Topics |
- Adult
- Anti-HIV Agents
(adverse effects)
- Anti-Retroviral Agents
(adverse effects)
- CD4 Lymphocyte Count
- Cohort Studies
- Confidence Intervals
- Disease Progression
- Drugs, Generic
- Female
- HIV Infections
(drug therapy, epidemiology, mortality)
- Humans
- Incidence
- India
(epidemiology)
- Logistic Models
- Male
- Medication Adherence
(statistics & numerical data)
- Odds Ratio
- Prospective Studies
- Reverse Transcriptase Inhibitors
(adverse effects)
- T-Lymphocytes
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