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Zidovudine (Retrovir)

A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.
Also Known As:
Retrovir; Azidothymidine; 3'-Azido-2',3'-Dideoxythymidine; 3'-Azido-3'-deoxythymidine; AZT Antiviral; AZT, Antiviral; BW A509U; BWA-509U; 3' Azido 2',3' Dideoxythymidine; 3' Azido 3' deoxythymidine; Antiviral AZT; BWA 509U; BWA509U; AZT (Antiviral); Thymidine, 3'-azido-3'-deoxy-
Networked: 3074 relevant articles (236 outcomes, 535 trials/studies)

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Drug Context: Research Results

Experts

1. Hermine, Olivier: 14 articles (11/2021 - 01/2002)
2. Bazarbachi, Ali: 12 articles (01/2020 - 01/2002)
3. Blanche, Stéphane: 11 articles (01/2022 - 09/2003)
4. Walker, Ulrich A: 9 articles (01/2014 - 11/2002)
5. Lockman, Shahin: 8 articles (01/2018 - 06/2006)
6. Makhema, Joseph: 8 articles (01/2018 - 06/2006)
7. Shapiro, Roger L: 8 articles (01/2018 - 06/2006)
8. Watts, D Heather: 8 articles (06/2012 - 07/2004)
9. Warszawski, Josiane: 7 articles (01/2022 - 04/2007)
10. Essex, Max: 7 articles (10/2017 - 06/2006)

Related Diseases

1. Acquired Immunodeficiency Syndrome (AIDS)
2. HIV Infections (HIV Infection)
3. Infections
4. AIDS-Related Complex (ARC)
5. Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated)

Related Drugs and Biologics

1. Zidovudine (Retrovir)
2. Interferon-alpha (Interferon Alfa)
3. Didanosine (Videx)
4. Lamivudine (Epivir)
5. Interferons
6. Antiviral Agents (Antivirals)
7. Nevirapine (Viramune)
8. Stavudine (Zerit)
9. Zalcitabine (Hivid)
10. Nucleosides

Related Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)
3. Highly Active Antiretroviral Therapy (HAART)
4. Cesarean Section (Caesarean Section)
5. Aftercare (After-Treatment)