Abstract | BACKGROUND: Preconditioning the brain with volatile anesthetics seems to be a viable option for reducing ischemic cerebral injury. However, it is uncertain whether this preconditioning effect extends over a longer period of time. The purpose of this study was to determine if sevoflurane preconditioning offers durable neuroprotection against cerebral ischemia. METHODS: RESULTS:
Sevoflurane preconditioning significantly improved functional outcome and reduced infarct volume (109 +/- 43 vs. 148 +/- 56 mm(3)) 3 days after ischemia compared to the control group. However, after 7- and 14-day recovery periods, no significant differences were observed between groups. The number of apoptotic cells was significantly lower in the preconditioned group than in the control group after 3- and 7-day recovery periods. Fourteen days after ischemia, no differences were observed between groups. CONCLUSION:
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Authors | Jean-Laurent Codaccioni, Lionel J Velly, Chahrazad Moubarik, Nicolas J Bruder, Pascale S Pisano, Benjamin A Guillet |
Journal | Anesthesiology
(Anesthesiology)
Vol. 110
Issue 6
Pg. 1271-8
(Jun 2009)
ISSN: 1528-1175 [Electronic] United States |
PMID | 19417596
(Publication Type: Journal Article)
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Chemical References |
- Anesthetics, Inhalation
- Methyl Ethers
- Neuroprotective Agents
- Sevoflurane
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Topics |
- Anesthetics, Inhalation
(pharmacology)
- Animals
- Apoptosis
(drug effects)
- Behavior, Animal
(physiology)
- Brain Ischemia
(pathology, physiopathology, prevention & control)
- DNA Fragmentation
- In Situ Nick-End Labeling
- Infarction, Middle Cerebral Artery
(pathology, prevention & control)
- Ischemic Attack, Transient
(physiopathology, prevention & control)
- Ischemic Preconditioning
- Methyl Ethers
(pharmacology)
- Nervous System Diseases
(pathology, psychology)
- Neuroprotective Agents
- Rats
- Rats, Sprague-Dawley
- Sevoflurane
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