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Deoxyuridine

2'-Deoxyuridine. An antimetabolite that is converted to deoxyuridine triphosphate during DNA synthesis. Laboratory suppression of deoxyuridine is used to diagnose megaloblastic anemias due to vitamin B12 and folate deficiencies.
Also Known As:
(beta 1-(2-Deoxyribopyranosyl))thymidine; Uridine, 2'-deoxy-
Networked: 331 relevant articles (12 outcomes, 28 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Hirano, Michio: 4 articles (01/2016 - 03/2003)
2. Adelstein, S James: 4 articles (05/2005 - 10/2002)
3. Kassis, Amin I: 4 articles (05/2005 - 10/2002)
4. Morgenroth, Agnieszka: 3 articles (10/2021 - 11/2008)
5. Martí, Ramon: 3 articles (01/2016 - 03/2003)
6. Vogg, Andreas T J: 3 articles (07/2014 - 06/2003)
7. Wang, Ketai: 3 articles (05/2005 - 11/2004)
8. Mottaghy, Felix M: 2 articles (10/2021 - 07/2014)
9. Jiang, Jian-Dong: 2 articles (01/2021 - 10/2020)
10. Baranowska-Kortylewicz, Janina: 2 articles (12/2020 - 03/2020)

Related Diseases

1. Neoplasms (Cancer)
2. Glioma (Gliomas)
3. Lymphoma (Lymphomas)
4. Prostatic Hyperplasia (Benign Prostatic Hyperplasia)
5. Infections
08/25/1979 - "Bacteriophage T5 induces a deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) activity during infection of Escherichia coli. "
01/01/2023 - "Brivudin, ((E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) can be considered the gold standard for the treatment of varicella-zoster virus (VZV) infections, such as herpes zoster (shingles). "
11/01/1999 - "The viral dUTPase may play a role in lowering the dUTP concentration in natural infections to minimize misincorporation of deoxyuridine into the viral DNA and ensure the fidelity of genome replication."
11/01/2003 - "The human protein apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like-3G (APOBEC3G), also known as CEM-15, mediates a newly described form of innate resistance to retroviral infection by catalyzing the deamination of deoxycytidine to deoxyuridine in viral cDNA replication intermediates. "
07/01/2016 - "Since the first antiviral drug, idoxuridine, was approved in 1963, 90 antiviral drugs categorized into 13 functional groups have been formally approved for the treatment of the following 9 human infectious diseases: (i) HIV infections (protease inhibitors, integrase inhibitors, entry inhibitors, nucleoside reverse transcriptase inhibitors, nonnucleoside reverse transcriptase inhibitors, and acyclic nucleoside phosphonate analogues), (ii) hepatitis B virus (HBV) infections (lamivudine, interferons, nucleoside analogues, and acyclic nucleoside phosphonate analogues), (iii) hepatitis C virus (HCV) infections (ribavirin, interferons, NS3/4A protease inhibitors, NS5A inhibitors, and NS5B polymerase inhibitors), (iv) herpesvirus infections (5-substituted 2'-deoxyuridine analogues, entry inhibitors, nucleoside analogues, pyrophosphate analogues, and acyclic guanosine analogues), (v) influenza virus infections (ribavirin, matrix 2 protein inhibitors, RNA polymerase inhibitors, and neuraminidase inhibitors), (vi) human cytomegalovirus infections (acyclic guanosine analogues, acyclic nucleoside phosphonate analogues, pyrophosphate analogues, and oligonucleotides), (vii) varicella-zoster virus infections (acyclic guanosine analogues, nucleoside analogues, 5-substituted 2'-deoxyuridine analogues, and antibodies), (viii) respiratory syncytial virus infections (ribavirin and antibodies), and (ix) external anogenital warts caused by human papillomavirus infections (imiquimod, sinecatechins, and podofilox). "

Related Drugs and Biologics

1. DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)
2. triphosphoric acid (triphosphate)
3. DNA (Deoxyribonucleic Acid)
4. Idoxuridine (Stoxil)
5. Enzymes
6. Nucleosides
7. brivudine (brivudin)
8. Thymidine Kinase
9. Methotrexate (Mexate)
10. Biotin (Vitamin H)

Related Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)
3. Injections
4. Adrenalectomy
5. Radiotherapy