Abstract | OBJECTIVE: STUDY DESIGN: RESULTS: The median ADAM12 value in trisomy 21 (0.961 MoM) was not significantly different from the euploid fetuses (1.013 MoM), but in trisomy 18 (0.697 MoM), trisomy 13 (0.577 MoM), triploidy (0.426 MoM), and Turner syndrome (0.747 MoM), the levels were significantly lower. In both the euploid and aneuploid pregnancies, there was a significant association between ADAM12 and free beta-hCG and PAPP-A. CONCLUSION: Maternal serum ADAM12 concentration at 11-13 weeks of gestation is unlikely to be useful in first-trimester screening for chromosomal abnormalities because in trisomy 21 the levels are not significantly different from normal, and in the other chromosomal defects, there is a significant association between ADAM12 and the traditional biochemical markers of free beta-hCG and PAPP-A.
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Authors | Leona C Y Poon, Teodora Chelemen, Ryoko Minekawa, Veronika Frisova, Kypros H Nicolaides |
Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 200
Issue 5
Pg. 508.e1-6
(May 2009)
ISSN: 1097-6868 [Electronic] United States |
PMID | 19285649
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Chorionic Gonadotropin
- Membrane Proteins
- ADAM Proteins
- ADAM12 Protein
- ADAM12 protein, human
- Pregnancy-Associated Plasma Protein-A
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Topics |
- ADAM Proteins
(blood)
- ADAM12 Protein
- Adolescent
- Adult
- Biomarkers
(blood)
- Case-Control Studies
- Chorionic Gonadotropin
(blood)
- Chromosome Aberrations
- Down Syndrome
(diagnosis)
- Female
- Humans
- Mass Screening
(methods)
- Membrane Proteins
(blood)
- Pregnancy
- Pregnancy Trimester, First
- Pregnancy-Associated Plasma Protein-A
(metabolism)
- Prenatal Diagnosis
(methods)
- Regression Analysis
- Turner Syndrome
(diagnosis)
- Young Adult
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